奎宁和奎尼丁对耐药性啮齿动物疟疾的血液裂殖体杀灭活性的比较评估。
Comparative evaluation of blood schizontocidal activity of quinine and quinidine against drug resistant rodent malaria.
作者信息
Kazim M, Puri S K, Dutta G P
机构信息
Central Drug Research Institute, Lucknow, India.
出版信息
J Commun Dis. 1991 Dec;23(4):254-6.
PMID:1842807
Abstract
Blood schizontocidal activity of quinine and quinidine has been compared against sensitive as well as chloroquine/mefloquine/quinine resistant strains of Plasmodium berghei and a multiple resistant strain of P. yoelii nigeriensis in Swiss mice. Evaluation of results on ED50/ED90 basis has shown distinct superiority of quinidine over quinine against sensitive as well as drug resistant strain of rodent malaria.
摘要
在瑞士小鼠中，已比较了奎宁和奎尼丁对伯氏疟原虫敏感株以及氯喹/甲氟喹/奎宁耐药株和约氏疟原虫尼日尔亚种多重耐药株的血内裂殖体杀灭活性。基于半数有效剂量（ED50）/90%有效剂量（ED90）对结果进行评估，结果表明，在对抗啮齿动物疟疾的敏感株和耐药株方面，奎尼丁明显优于奎宁。
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