Bankiewicz K S, Sanchez-Pernaute R, Oiwa Y, Kohutnicka M, Cummins A, Eberling J
National Institute of Neurological Disorders and Stroke (NIH), Bethesda, Maryland, USA.
Curr Protoc Neurosci. 2001 May;Chapter 9:Unit9.4. doi: 10.1002/0471142301.ns0904s09.
Parkinson's disease is a neurodegenerative disease in which pigmented midbrain neurons progressively die producing a dopamine (DA) deficit in the striatum which manifests as an akinetic movement disorder. Experimentally induced striatal DA depletion in animals is a valid model of parkinsonism. The capacity of certain substances to damage catecholaminergic neurones has been used for a long time to produce DA deficiency in animals. This unit focuses on methods for inducing parkinsonism using the neurotoxins MPTP and 6-hydroxy dopamine and methods for evaluating the animals. Other models are briefly reviewed.
帕金森病是一种神经退行性疾病，其中脑黑质色素神经元逐渐死亡，导致纹状体中多巴胺（DA）缺乏，表现为运动不能性运动障碍。实验诱导动物纹状体DA耗竭是帕金森病的有效模型。某些物质损害儿茶酚胺能神经元的能力长期以来一直被用于在动物中产生DA缺乏。本单元重点介绍使用神经毒素MPTP和6-羟基多巴胺诱导帕金森病的方法以及评估动物的方法。其他模型将简要回顾。
