逆转录病毒脑病的动物模型：猫科动物模型。

Animal models of retroviral encephalopathies: feline model.

作者信息

Podell Michael, Buck Wayne R, Hayes Kathleen A, Gavrilin Mikhail A, Mathes Lawrence E

机构信息

The Ohio State University, Columbus, Ohio, USA.

出版信息

Curr Protoc Neurosci. 2002 Feb;Chapter 9:Unit 9.9. doi: 10.1002/0471142301.ns0909s17.

DOI:10.1002/0471142301.ns0909s17

PMID:18428574

Abstract

Human immunodeficiency virus infection in children and adults results in a progressive neurodegenerative disease consistent with a predominant subcortical mediated dementia. Techniques for developing a feline model of the early stages of lentiviral-associated neurodegeneration are presented. The behavioral, neurophysiologic, immunologic, virologic, and neuropathologic aspects of this model are also described.

摘要

儿童和成人感染人类免疫缺陷病毒会导致一种进行性神经退行性疾病，与主要由皮质下介导的痴呆症相符。本文介绍了建立慢病毒相关神经退行性变早期阶段猫模型的技术。还描述了该模型的行为、神经生理学、免疫学、病毒学和神经病理学方面。