Platt Donna M, Carey Galen, Spealman Roger D
New England Primate Research Center Harvard Medical School, Southborough, Massachusetts, USA.
Curr Protoc Neurosci. 2005 Aug;Chapter 9:Unit 9.21. doi: 10.1002/0471142301.ns0921s32.
Drug self-administration is a procedure in which a subject performs a response, called an operant, that results in the delivery of a drug injection. This procedure is viewed as a relevant model for the study of human drug-taking behavior. Drug self-administration in primates has several characteristics that resemble drug-taking behavior in humans, and drugs that are commonly abused by humans also typically maintain self-administration behavior in monkeys. Drug self-administration procedures allow for the study of a variety of drug properties. For instance, they are used to investigate the abuse potential of new compounds and to study the effects of candidate medications for the treatment of drug addiction. These procedures also can be used to study the process of drug reinforcement. This unit describes intravenous drug self-administration in large primates, such as rhesus macaques, and smaller primates, such as squirrel monkeys.
药物自我给药是一种实验程序，在该程序中，实验对象执行一种被称为操作性反应的行为，这种行为会导致药物注射的给予。该程序被视为研究人类药物使用行为的相关模型。灵长类动物的药物自我给药具有一些与人类药物使用行为相似的特征，并且人类常用的滥用药物通常也能维持猴子的自我给药行为。药物自我给药程序有助于研究多种药物特性。例如，它们被用于研究新化合物的滥用潜力，以及研究用于治疗药物成瘾的候选药物的效果。这些程序还可用于研究药物强化过程。本单元描述了在恒河猴等大型灵长类动物以及松鼠猴等小型灵长类动物中进行的静脉药物自我给药。
