Arenas Aylan Farid, Escobar Andrés J Gutierrez, Gómez-Marin Jorge Enrique
Grupo de Parasitología Molecular (GEPAMOL), Centro de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad del Quindío, Armenia, Colombia.
In Silico Biol. 2008;8(1):15-20.
The histone-like proteins (HU) belong to a family of DNA architectural proteins that stabilize nucleoprotein complexes. We found a putative HU protein (TgGlmHMM_3045) in Toxoplasma gondii genome that was homologous to the bacterial HU protein. This putative sequence was located in the scaffold TGG_995361 of the chromosome 10. The sequence included the prokaryotic bacterial histone-like domain, KFGSLGlRRRGERVARNPRT (ID number PS00045). HU protein sequences were also found in Plasmodium falciparum, Neospora caninum, Theileria parva and Theileria annulata. We found that the homology of the putative HU protein in Apicomplexa was greater with bacterial histone-like proteins than with eukaryotic histone proteins. The phylogenetic tree indicated that the putative HU protein genes were acquired in Apicomplexa by means of a secondary endosymbiotic event from red algae and later they were transferred from the apicoplast organelle to the nuclear genome.
类组蛋白（HU）属于一类能稳定核蛋白复合物的DNA结构蛋白家族。我们在刚地弓形虫基因组中发现了一种假定的HU蛋白（TgGlmHMM_3045），它与细菌的HU蛋白同源。该假定序列位于10号染色体的支架TGG_995361上。该序列包含原核细菌类组蛋白结构域，KFGSLGlRRRGERVARNPRT（标识符PS00045）。在恶性疟原虫、犬新孢子虫、小泰勒虫和环形泰勒虫中也发现了HU蛋白序列。我们发现，顶复门中假定的HU蛋白与细菌类组蛋白的同源性高于与真核组蛋白的同源性。系统发育树表明，顶复门中的假定HU蛋白基因是通过二次内共生事件从红藻获得的，随后从顶质体细胞器转移到核基因组中。
Zotero 插件