[深圳学龄前儿童血清甘露聚糖结合凝集素水平]

[Serum mannan-binding lectin levels in preschool children from Shenzhen].

作者信息

Chen Wei-Dong, Xiao Qin, Zou De-Xue

机构信息

Department of Clinical Laboratory, Shenzhen Hospital, Peking University, Shenzhen, Guangdong 518036, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2008 Apr;10(2):149-51.

PMID:18433533

Abstract

OBJECTIVE

Mannan-binding lectin (MBL) is a C-type serum lectin that plays a central role in the innate immune response. At present there is no a reference range of serum MBL levels for children in China. This study investigated serum MBL levels in preschool children from Shenzhen.

METHODS

A total of 118 children (62 boys and 56 girls) at ages of 3-6 years and sampled randomly from three kindergartens of Shenzhen were enrolled in this study. Serum MBL concentrations were determined using enzyme-linked immunosorbent assay.

RESULTS

The mean serum MBL concentration in these children was 779.07+/-268.98 ng/mL. There were no significant differences in the value of serum MBL between boys and girls (783.89+/-252.30 ng/mL vs 773.65+/-288.29 ng/mL) (P>0.05). Sixteen children (13.6%) had MBL concentrations less than 500 ng/mL (the low limited value used abroad), including 14 cases with 50-500 ng/mL and 2 cases with less than 50 ng/mL.

CONCLUSIONS

This study provides a reference range of serum MBL concentration for preschool children. MBL may be a useful marker for the prevention of infection in children.

摘要

目的

甘露聚糖结合凝集素（MBL）是一种C型血清凝集素，在先天性免疫反应中起核心作用。目前中国尚无儿童血清MBL水平的参考范围。本研究调查了深圳学龄前儿童的血清MBL水平。

方法

本研究纳入了从深圳三所幼儿园随机抽取的118名3至6岁儿童（62名男孩和56名女孩）。采用酶联免疫吸附测定法测定血清MBL浓度。

结果

这些儿童的血清MBL平均浓度为779.07±268.98 ng/mL。男孩和女孩的血清MBL值无显著差异（783.89±252.30 ng/mL对773.65±288.29 ng/mL）（P>0.05）。16名儿童（13.6%）的MBL浓度低于500 ng/mL（国外使用的低限值），其中14例为50 - 500 ng/mL，2例低于50 ng/mL。