Kannerup Anne-Sofie, Nielsen Dennis Tømrer, Sørensen Steen Mellerup, Mortensen Frank Viborg
Arhus Universitetshospital, Arhus Sygehus, Kirurgisk Gastroenterologisk Afdeling L, Arhus.
Ugeskr Laeger. 2008 Apr 14;170(16):1338-41.
Liver resection in combination with radiofrequency ablation (RFA) is a novel approach in patients with colorectal liver metastases who are otherwise unresectable.
Eighteen patients with colorectal liver metastases were treated with surgical resection combined with RFA. All patients were followed prospectively with CT-scanning of thorax and abdomen during a 5-year period, 1, 4, 8 and 12 months after treatment and every 6 months thereafter for the following 4 years. Main outcome was recurrence and survival.
Eleven male and 7 female patients with a median age of 65 years (41-78) were treated with combined surgery and RFA. 76 metastases were treated, 34 of these with resection. The median survival rate in the entire group was 35 months. 5-years overall survival was 34%. 12 patients had recurrence and were treated with multimodality therapy.
Combined surgery and RFA treatment was a good alternative in a group of patients with colorectal liver metastases that were otherwise only suitable for systemic chemotherapy.
肝切除联合射频消融（RFA）是治疗无法切除的结直肠癌肝转移患者的一种新方法。
18例结直肠癌肝转移患者接受了手术切除联合RFA治疗。在5年期间，对所有患者进行前瞻性随访，治疗后1、4、8和12个月以及之后4年每6个月进行一次胸部和腹部CT扫描。主要结局指标为复发和生存情况。
11例男性和7例女性患者接受了手术联合RFA治疗，中位年龄65岁（41 - 78岁）。共治疗76处转移灶，其中34处进行了切除。整个组的中位生存率为35个月。5年总生存率为34%。12例患者出现复发并接受了多模式治疗。
对于一组原本仅适合全身化疗的结直肠癌肝转移患者，手术联合RFA治疗是一种较好的选择。
