Dolcetti Luigi, Marigo Ilaria, Mantelli Barbara, Peranzoni Elisa, Zanovello Paola, Bronte Vincenzo
Department of Oncology and Surgical Sciences, Via Gattamelata 64, 35128 Padova, Italy.
Cancer Lett. 2008 Aug 28;267(2):216-25. doi: 10.1016/j.canlet.2008.03.012. Epub 2008 Apr 22.
Chronic inflammatory state can create a proper environment for neoplastic onset and sustain cancer growth. The inflammatory state that arises at the tumor edge could contribute to immune escape phenomena in many ways. Myeloid-derived suppressor cells (MDSCs), a cell population that contributes to tumor escape, immune tolerance, and suppression, respond to a variety of pro-inflammatory and anti-inflammatory stimuli, which drive their recruitment and activation. Understanding how the inflammatory milieu favours tumor escape through the accumulation of MDSCs could be very useful to improve the efficacy of cancer immunotherapy.
慢性炎症状态可为肿瘤发生创造适宜环境并维持癌症生长。肿瘤边缘出现的炎症状态可通过多种方式促成免疫逃逸现象。髓源性抑制细胞（MDSCs）是一类有助于肿瘤逃逸、免疫耐受和抑制的细胞群体，可对多种促炎和抗炎刺激作出反应，这些刺激会促使其募集和激活。了解炎症微环境如何通过MDSCs的积累促进肿瘤逃逸，可能对提高癌症免疫治疗的疗效非常有用。
