脱氨基紫外线过滤剂3-羟基犬尿氨酸O-β-D-葡萄糖苷存在于患有白内障的人晶状体中。
Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses.
作者信息
Snytnikova Olga A, Fursova Anjella Zh, Chernyak Elena I, Vasiliev Vladimir G, Morozov Sergey V, Kolosova Nataliya G, Tsentalovich Yuri P
机构信息
Department of Multispin Coordination Compounds, International Tomography Center SB RAS, Institutskaya 3a, Novosibirsk 630090, Russian Federation.
出版信息
Exp Eye Res. 2008 Jun;86(6):951-6. doi: 10.1016/j.exer.2008.03.013. Epub 2008 Mar 26.
Analysis of UV filter levels in 48 cataractous human lenses was performed with the use of HPLC. A new chromophore with the absorption maximum at 410nm and molecular mass of 369Da was detected and assigned as deaminated 3-hydroxykynurenine O-beta-D-glucoside (3OHCKAG). Cataractous lenses are characterized by the wide range of the UV filter concentrations and remarkably lower levels of UV filters and glutathione than published for the normal lenses. No correlation between the lens age and the level of UV filters has been found in cataractous lenses.
利用高效液相色谱法对48个人类白内障晶状体中的紫外线过滤剂水平进行了分析。检测到一种新的发色团，其最大吸收波长为410nm，分子量为369Da，并将其确定为脱氨基3-羟基犬尿氨酸O-β-D-葡萄糖苷（3OHCKAG）。白内障晶状体的特点是紫外线过滤剂浓度范围广泛，与正常晶状体相比，紫外线过滤剂和谷胱甘肽水平显著降低。在白内障晶状体中未发现晶状体年龄与紫外线过滤剂水平之间的相关性。
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