[ Merkel细胞癌与免疫抑制：三例报告及治疗选择综述 ]

[Merkel cell carcinoma and immunosuppression: report of three cases and review of therapeutic options].

作者信息

Gröger A, Piatkowski A, Unglaub F, Bozkurt A, Pallua N

机构信息

Klinik für Plastische Chirurgie, Hand- und Verbrennungschirurgie, RWTH-Universitätsklinikum Aachen.

出版信息

Handchir Mikrochir Plast Chir. 2008 Apr;40(2):105-9. doi: 10.1055/s-2007-965760.

DOI:10.1055/s-2007-965760

PMID:18437669

Abstract

Merkel cell carcinoma (MCC) is a cutaneous, neuroendocrine tumour of high malignancy that is described as a firm, purple tumour localised in the dermal layer. Due to its high progression rate, the 5-year survival rate is quoted as between 30 and 74 %. The course of disease is characterised by high relapse rate (30 - 77 %) and lymph node metastases (ca. 50 %). Therapy of MCC is based on a radical surgical excision combined with sentinel lymph node biopsy (stadium I), lymph node dissection (stadium II) and postoperative radiotherapy. We report three cases of MCC under immunosuppression and present therapeutic options of MCC in overview.

摘要

默克尔细胞癌（MCC）是一种皮肤神经内分泌肿瘤，恶性程度高，表现为位于真皮层的坚实紫色肿瘤。由于其高进展率，5年生存率据报在30%至74%之间。疾病进程的特点是高复发率（30%-77%）和淋巴结转移（约50%）。MCC的治疗基于根治性手术切除，联合前哨淋巴结活检（I期）、淋巴结清扫（II期）及术后放疗。我们报告3例免疫抑制状态下的MCC病例，并概述MCC的治疗选择。