持续动脉内注入卡铂联合放疗治疗局部晚期舌癌的疗效

Treatment results of continuous intra-arterial CBDCA infusion chemotherapy in combination with radiation therapy for locally advanced tongue cancer.

作者信息

Fuwa Nobukazu, Kodaira Takeshi, Furutani Kazuhisa, Tachibana Hiroyuki, Nakamura Tatsuya

机构信息

Department of Radiation Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

出版信息

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jun;105(6):714-9. doi: 10.1016/j.tripleo.2007.11.023. Epub 2008 Apr 24.

DOI:10.1016/j.tripleo.2007.11.023

PMID:18439857

Abstract

OBJECTIVE

The objective of this study was to improve the treatment results for locally advanced tongue cancer. A combination of radiotherapy with continuous intra-arterial therapy using CBDCA was used.

STUDY DESIGN

According to TNM staging (1997), 29 patients had stage III lesions and 11 patients had stage IV (M0) lesions. A catheter was inserted through the lingual artery in 26 patients, through the external carotid artery in 11 patients, and through the faciolingual trunk in 2 patients. CBDCA was continuously infused for 4 to 6 weeks. With IA chemotherapy, external irradiation (median dose: 46.8 Gy) was simultaneously performed, and 1 to 2 courses of systemic chemotherapy were performed in 19 patients before intra-arterial chemotherapy.

RESULTS

The 5-year local control rate was 65%. The 5-year OS rate was 39.5%. There were no clinically significant adverse side effects.

CONCLUSION

Continuous IA CBDCA and concurrent radiation therapy can be delivered safely with good efficacy for locally advanced carcinoma of the tongue.

摘要

目的

本研究的目的是改善局部晚期舌癌的治疗效果。采用放疗联合使用卡铂的持续动脉内治疗。

研究设计

根据TNM分期（1997年），29例患者为III期病变，11例患者为IV期（M0）病变。26例患者通过舌动脉插入导管，11例患者通过颈外动脉插入导管，2例患者通过面舌干插入导管。卡铂持续输注4至6周。在进行动脉内化疗时，同时进行外照射（中位剂量：46.8 Gy），19例患者在动脉内化疗前进行了1至2个疗程的全身化疗。