Quinn Jennifer J, Ma Quang D, Tinsley Matthew R, Koch Christof, Fanselow Michael S
Department of Psychology and Brain Research Institute, UCLA, Los Angeles, California 90095-1563, USA.
Learn Mem. 2008 Apr 25;15(5):368-72. doi: 10.1101/lm.813608. Print 2008 May.
Retrograde amnesia following disruptions of hippocampal function is often temporally graded, with recent memories being more impaired. Evidence supports the existence of one or more neocortical long-term memory storage/retrieval site(s). Neurotoxic lesions of the medial prefrontal cortex (mPFC) or the dorsal hippocampus (DH) were made 1 day or 200 days following trace fear conditioning. Recently encoded trace fear memories were most disrupted by DH lesions, while remotely encoded trace and contextual memories were most disrupted by mPFC lesions. These data strongly support the consolidation theory of hippocampus function and implicate the mPFC as a site of long-term memory storage/retrieval.
海马体功能中断后出现的逆行性遗忘通常在时间上呈梯度变化,近期记忆受损更严重。有证据支持存在一个或多个新皮质长期记忆存储/提取位点。在痕迹恐惧条件反射后1天或200天,对内侧前额叶皮质(mPFC)或背侧海马体(DH)进行神经毒性损伤。近期编码的痕迹恐惧记忆受DH损伤的影响最大,而远期编码的痕迹和情境记忆受mPFC损伤的影响最大。这些数据有力地支持了海马体功能的巩固理论,并表明mPFC是长期记忆存储/提取的位点。