Castro M, Contreras M C, Salinas P
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad de Chile, Santiago.
Bol Chil Parasitol. 1991 Jul-Dec;46(3-4):85-8.
Even though Toxoplasma gondii is an ubiquitous parasite that can effect most of human structures and organs, not all clinical manifestations suggestive of being produced by it are caused by this protozoon. For these reasons sera samples of patients suspected of having toxoplasmosis are sent to the laboratory for detecting specific antibodies which would facilitate the differential diagnosis. Thus, 716 sera from suspected patients, mainly from the Metropolitan Region of Chile, were sent to the Parasitology Laboratory of Chile University in order to carry out in them, specific serological tests for toxoplasmosis: indirect hemagglutination test (IHAT), Sabin Feldman reaction (SFT) and complement fixation test (CFT). Were considered positive: IHAT and/or SFT with titers > or = 1:16 and CFT with titer > or = 1:5. The pathologies for demanding these serological tests were obstetrical problems 210 (29.3%), congenital problems 193 (27.0%), ophthalmopathies 81 (11.3%), adenopathies 77 (10.8%), AIDS 67 (9.4%), myocardiopathies 46 (6.4%) and miscellaneous 42 (5.9%). The positivity found in these sera was higher in ophthalmopathies (61.7%), followed by obstetrical problems, miscellaneous problems, myocardiopathies and AIDS (50.7-52.4%), less frequent was the positivity in adenopathies (35.1%) and congenital problems (23.1%). In general, the 43.7% of positivity for toxoplasmosis found in these patients is higher than the 37.0% found in the general population. High titers of IHAT and SFT plus positive CFT was found in 13-fold higher proportion than in the general population.
尽管刚地弓形虫是一种普遍存在的寄生虫,可影响人体的大多数组织和器官,但并非所有提示由其引起的临床表现都是由这种原生动物导致的。基于这些原因,疑似患有弓形虫病患者的血清样本会被送往实验室检测特异性抗体,这将有助于鉴别诊断。因此,716份主要来自智利首都大区疑似患者的血清样本被送往智利大学寄生虫学实验室,以便对这些样本进行弓形虫病的特异性血清学检测:间接血凝试验(IHAT)、Sabin Feldman反应(SFT)和补体结合试验(CFT)。若IHAT和/或SFT滴度>或=1:16且CFT滴度>或=1:5,则判定为阳性。要求进行这些血清学检测的病症包括产科问题210例(29.3%)、先天性问题193例(27.0%)、眼病81例(11.3%)、腺病77例(10.8%)、艾滋病67例(9.4%)、心肌病46例(6.4%)和其他杂症42例(5.9%)。这些血清样本中,眼病患者的阳性率最高(61.7%),其次是产科问题、杂症、心肌病和艾滋病患者(50.7 - 52.4%),腺病患者(35.1%)和先天性问题患者(23.1%)的阳性率较低。总体而言,这些患者中弓形虫病的阳性率为43.7%,高于普通人群中的37.0%。发现高滴度的IHAT和SFT以及阳性CFT的比例比普通人群高13倍。