Azofeifa J, Barrantes R
Instituto de Investigaciones en Salud (INISA), Universidad de Costa Rica.
Rev Biol Trop. 1991 Nov;39(2):249-53.
A screening of more than 40 loci was performed in the Bribri and Cabecar Amerindian populations of Talamanca in Southeastern Costa Rica. Some differences were found in the distribution (presence or absence) of the variants (some of them private) of the GOT, PEPA, RH, TF and TPI loci when the results reported here were compared with those of the Bribris and Cabecars that inhabit in the Pacific side of the country. Admixture with non-Indians was detected at the ABO, ADA, and G6PD loci. The proportion of polymorphic loci (P) found were 17.1 in the Bribris and 19.4 in the Cabecars; their average heterozygosites (H) estimates were 0.039 and 0.049 respectively. Fst values (0.019 in the Bribris and 0.056 in the Cabecars) seem to indicate that random events have played important roles in the divergence of the Cabecars. Low effective population sizes of the emigrant groups to the Pacific side and probable gene flow in the case of the Bribris, could be the cause of these differences.
在哥斯达黎加东南部塔拉曼卡的布里布里和卡韦卡尔美洲印第安人群体中，对40多个基因座进行了筛查。当将此处报告的结果与居住在该国太平洋沿岸的布里布里人和卡韦卡尔人的结果进行比较时，发现谷丙转氨酶（GOT）、肽酶A（PEPA）、恒河猴血型（RH）、转铁蛋白（TF）和磷酸丙糖异构酶（TPI）基因座的变体（其中一些是特有变体）在分布（存在或不存在）上存在一些差异。在ABO、腺苷脱氨酶（ADA）和葡萄糖-6-磷酸脱氢酶（G6PD）基因座检测到与非印第安人的混合情况。在布里布里人中发现的多态性基因座比例（P）为17.1，在卡韦卡尔人中为19.4；它们的平均杂合度（H）估计值分别为0.039和0.049。固定指数值（Fst）（布里布里人为0.019，卡韦卡尔人为0.056）似乎表明随机事件在卡韦卡尔人的分化中发挥了重要作用。向太平洋沿岸迁移的群体有效种群规模较小，以及布里布里人可能存在的基因流动，可能是造成这些差异的原因。
