Alvear J, Vial M, Artaza C
INTA, Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile.
Rev Chil Pediatr. 1991 Jul-Aug;62(4):242-7.
In order to investigate growth following early severe malnutrition, two groups of 40 children and their mothers were studied, one of patients recovered from early protein energy malnutrition (PEM) at a closed center for nutritional recovery and another one of children under the same socioeconomic condition but who had never been malnourished. Both groups were matched for sex and age, and were followed by the same professional team for 9 years. A significant difference in mother's size (154.8 +/- 5.2 vs. 150 +/- 3.6 cm) and in patients size at birth (males 3,453.5 +/- 522.3 vs. 3,018.2 +/- 490.3 and females 3,328.4 +/- 563.4 vs. 2,654.6 +/- 579.6 g) was found in favour of the control group (p < 0.01). There were significant differences in height for age (H/A) and weight for age (W/A) (p < 0.001) but not in weight for height ratios between children for both groups (fig. 1 and 2). No differences were detected in bone age. Growth velocity was similar in both groups of boys (10.40 +/- 2.3 vs. 9.81 +/- 1.40 cm and 12.94 +/- 2.53 vs. 12.80 +/- 1.64 cm from 5 to 7 and 7 to 9 years of age respectively) but it was significantly greater in control girls (11.22 +/- 2.70 vs. 9.30 +/- 1.60 and 15.60 +/- 1.66 vs. 12.80 +/- 2.20 cm 5 to 7 and 7 to 9 years respectively, p < 0.01). These findings show that malnutrition before 2 years of age may produce long term effects on growth in children of low socioeconomic condition specially if, after treatment, they are turned back to the same unfavourable environment.
为了研究早期严重营养不良后的生长情况,对两组各40名儿童及其母亲进行了研究,一组是在封闭的营养康复中心从早期蛋白质能量营养不良(PEM)中康复的患者,另一组是处于相同社会经济状况但从未营养不良的儿童。两组在性别和年龄上进行了匹配,并由同一专业团队跟踪随访9年。结果发现,对照组在母亲身高(154.8±5.2对150±3.6厘米)和患儿出生时的身高(男性3453.5±522.3对3018.2±490.3克,女性3328.4±563.4对2654.6±579.6克)方面具有显著优势(p<0.01)。两组儿童的年龄别身高(H/A)和年龄别体重(W/A)存在显著差异(p<0.001),但身高别体重比无差异(图1和图2)。骨龄未检测到差异。两组男孩的生长速度相似(5至7岁分别为10.40±2.3对9.81±1.40厘米,7至9岁分别为12.94±2.53对12.80±1.64厘米),但对照组女孩的生长速度显著更快(5至7岁分别为11.22±2.70对9.30±1.60厘米,7至9岁分别为15.60±1.66对12.80±2.20厘米,p<0.01)。这些发现表明,2岁前的营养不良可能会对社会经济状况较差的儿童的生长产生长期影响,特别是如果治疗后他们又回到相同的不利环境中。