西咪替丁对克氏锥虫感染大鼠脾细胞增殖反应的免疫调节作用。

Immunomodulatory effect of cimetidine on the proliferative responses of splenocytes from T. cruzi-infected rats.

作者信息

Sato M N, Yamashiro-Kanashiro E H, Tanji M M, Kaneno R, Iqueoka R Y, Duarte A J

机构信息

Laboratório de Imunogenética e Transplante Experimental (LIM 73), Faculdade de Medicina, Universidade de São Paulo, Brazil.

出版信息

Rev Inst Med Trop Sao Paulo. 1991 May-Jun;33(3):187-92. doi: 10.1590/s0036-46651991000300004.

DOI:10.1590/s0036-46651991000300004

PMID:1844533

Abstract

The immunomodulatory effect of cimetidine (CIM), a histamine type-2 receptor antagonist, was evaluated in respect to the blastogenic response to Con A of Wistar Furth (WF) rats infected by the Y strain of Trypanosoma cruzi (T. cruzi). Enhancement of blastogenesis of normal splenocytes was observed at a concentration of 10(3) M. However, the splenocytes from infected animals responded to concentrations of CIM ranging from 10(-8) to 10(-3) M. The mitogenic response to Con A of cells from infected animals was restored in the presence of CIM. The results show that CIM modulates the "in vitro" proliferative response of cells from T. cruzi-infected rats and suggest an immunoregulatory role of histamine and/or of cells that express H2 receptors in this infection.

摘要

研究了组胺2型受体拮抗剂西咪替丁（CIM）对感染克氏锥虫（T. cruzi）Y株的Wistar Furth（WF）大鼠对刀豆蛋白A（Con A）的致有丝分裂反应的免疫调节作用。在浓度为10³ M时观察到正常脾细胞的有丝分裂增强。然而，来自感染动物的脾细胞对浓度范围为10⁻⁸至10⁻³ M的CIM有反应。在CIM存在的情况下，感染动物细胞对Con A的促有丝分裂反应得以恢复。结果表明，CIM调节克氏锥虫感染大鼠细胞的“体外”增殖反应，并提示组胺和/或表达H2受体的细胞在这种感染中具有免疫调节作用。