Wilfred de Alwis Nimantha Mark, Day Christopher Paul
Curr Diab Rep. 2008 Apr;8(2):156-63. doi: 10.1007/s11892-008-0027-9.
Whereas most individuals with nonalcoholic fatty liver disease (NAFLD) will have steatosis, only a minority will ever develop progressive disease. Family studies and interethnic variations in susceptibility suggest that genetic factors may be important in determining disease risk. Although no genetic associations with advanced NAFLD have been replicated in large studies, preliminary data suggest that polymorphisms in the genes encoding microsomal triglyceride transfer protein, superoxide dismutase 2, the CD14 endotoxin receptor, tumor necrosis factor-alpha, transforming growth factor-beta, and angiotensinogen may be associated with steatohepatitis and/or fibrosis. With the advent of high-throughput gene analyses and the reduced cost of whole genome-wide scans, it seems likely that genes contributing to inherited susceptibility to this common disease will be identified in the near future.
虽然大多数非酒精性脂肪性肝病（NAFLD）患者会出现脂肪变性，但只有少数人会发展为进行性疾病。家族研究和不同种族间易感性的差异表明，遗传因素可能在决定疾病风险方面起重要作用。尽管在大型研究中尚未重复证实与晚期NAFLD相关的遗传关联，但初步数据表明，编码微粒体甘油三酯转移蛋白、超氧化物歧化酶2、CD14内毒素受体、肿瘤坏死因子-α、转化生长因子-β和血管紧张素原的基因中的多态性可能与脂肪性肝炎和/或纤维化有关。随着高通量基因分析的出现以及全基因组扫描成本的降低，在不久的将来有可能识别出导致这种常见疾病遗传易感性的基因。
