Davis Janae M, Krew Michael A, Gill Prabhcharan, Nelson Karl M, Hopkins Michael P
Department of Obstetrics and Gynecology, Aultman Health Foundation, Canton, Ohio, USA.
J Matern Fetal Neonatal Med. 2008 May;21(5):301-4. doi: 10.1080/14767050802022789.
Continuous fetal monitoring (CFM) is often used in the management of preterm premature rupture of membranes (PPROM) but there is little evidence to support this approach. The objective of this study was to evaluate the clinical outcome of PPROM when managed by CFM.
A retrospective review was conducted of 129 cases PPROM outcomes for the period January 1, 1998 to December 31, 2003. All women underwent CFM. Delivery was carried out for non-reassuring fetal testing, vaginal bleeding, evidence of infection, positive vaginal pool phosphatidylglycerol when available, and spontaneous labor.
Delivery was carried out because of an abnormal fetal heart tracing in 15 women (11.7%). The mean gestational age at admission was 32.2 weeks (95% CI 31.7-32.7), the mean gestational age at delivery was 32.7 weeks (95% CI 32.2-33.1), and the mean latency period was 3.3 days (95% CI 1.5-5.0). Gestational age at rupture of membranes was inversely correlated with latency period (n = 128, r = -0.372, p < 0.001). With regard to gestational age, gravidity, and latency period there was no significant difference noted with respect to why the subjects delivered. No intrauterine deaths occurred in the study.
In our series, fetal heart rate tracing abnormalities were the indication for delivery in a small but significant percentage of conservatively managed PPROM cases. Our review suggests that a prospective trial of CFM versus intermittent monitoring techniques should be carried out.
连续胎儿监护(CFM)常用于未足月胎膜早破(PPROM)的处理,但几乎没有证据支持这种方法。本研究的目的是评估采用CFM处理PPROM的临床结局。
对1998年1月1日至2003年12月31日期间129例PPROM的结局进行回顾性分析。所有孕妇均接受CFM。因胎儿检测结果不令人放心、阴道出血、有感染迹象、如有阴道积液中磷脂酰甘油阳性以及自然临产而行分娩。
15名妇女(11.7%)因胎儿心率异常而行分娩。入院时平均孕周为32.2周(95%可信区间31.7 - 32.7),分娩时平均孕周为32.7周(95%可信区间32.2 - 33.1),平均潜伏期为3.3天(95%可信区间1.5 - 5.0)。胎膜破裂时的孕周与潜伏期呈负相关(n = 128,r = -0.372,p < 0.001)。关于孕周、妊娠次数和潜伏期,在受试者分娩原因方面未发现显著差异。本研究中未发生宫内死亡。
在我们的系列研究中,在一小部分但比例可观的保守处理的PPROM病例中,胎儿心率异常是分娩的指征。我们的综述表明,应进行一项CFM与间歇性监护技术对比的前瞻性试验。