Entringer Sonja, Wüst Stefan, Kumsta Robert, Layes Irmgard M, Nelson Edward L, Hellhammer Dirk H, Wadhwa Pathik D
Department of Psychobiology, University of Trier, Germany.
Am J Obstet Gynecol. 2008 Nov;199(5):498.e1-7. doi: 10.1016/j.ajog.2008.03.006. Epub 2008 Apr 29.
The objective of the study was to examine the association in humans between maternal psychosocial stress exposure during pregnancy and measures of glucose-insulin metabolism in the adult offspring.
Healthy young adults whose mothers experienced major stressful life events during their pregnancy (n = 36, prenatal stress, PS group, mean age 25 +/- 5.14 [SD] years) and a comparison group (n = 22, CG, mean age 24 +/- 3.7 [SD] years) underwent an oral glucose tolerance test.
Glucose levels were not significantly different across the groups; however, prenatally stressed subjects showed significantly elevated 2-hour insulin (P = .01) and C-peptide levels (P = .03). These differences were independent of other major risk factors for insulin resistance, including birth phenotype (birthweight, length of gestation), a family history of diabetes, gestational diabetes, body mass index, proinflammatory state, and smoking.
Higher insulin responses reflect relative insulin resistance in these prenatally stressed young adults. This study is the first to provide evidence for a link in humans between prenatal psychosocial stress exposure and alterations in glucose-insulin metabolic function.
本研究的目的是探讨孕期母亲心理社会应激暴露与成年后代葡萄糖 - 胰岛素代谢指标之间的关联。
母亲在孕期经历重大生活应激事件的健康年轻成年人（n = 36，产前应激组，PS组，平均年龄25±5.14 [标准差]岁）和一个对照组（n = 22，CG组，平均年龄24±3.7 [标准差]岁）接受了口服葡萄糖耐量试验。
各组间血糖水平无显著差异；然而，产前应激受试者的2小时胰岛素水平（P = .01）和C肽水平（P = .03）显著升高。这些差异独立于胰岛素抵抗的其他主要危险因素，包括出生表型（出生体重、孕周）、糖尿病家族史、妊娠期糖尿病、体重指数、促炎状态和吸烟。
较高的胰岛素反应反映了这些产前应激年轻成年人的相对胰岛素抵抗。本研究首次为人类产前心理社会应激暴露与葡萄糖 - 胰岛素代谢功能改变之间的联系提供了证据。
