口腔鳞状细胞癌中肿瘤坏死因子α、白细胞介素1α、白细胞介素6和白细胞介素8的唾液浓度。
Salivary concentration of TNFalpha, IL1 alpha, IL6, and IL8 in oral squamous cell carcinoma.
作者信息
SahebJamee Mahnaz, Eslami Mohammad, AtarbashiMoghadam Fazele, Sarafnejad Abdolfattah
机构信息
Department of Oral Medicine, Faculty of Dentistry, Dental Research Center, Tehran University of Medical Science, Tehran, Iran.
出版信息
Med Oral Patol Oral Cir Bucal. 2008 May 1;13(5):E292-5.
OBJECTIVES
The aim of this study was to compare the concentration of tumor necrosis factor alpha, interleukin 1 alpha, 6, and 8 in the saliva of oral squamous cell carcinoma patients with control group.
STUDY DESIGN
In this study 18 subjects were involved, nine patients with oral squamous cell carcinomas and nine age-sex-matched healthy individuals that were matched for gingival conditions too. Active dental abscesses, collagen vascular diseases, and infectious diseases during one month before saliva sampling were considered as exclusion criteria. Unstimulated whole saliva was collected and after processing the samples were analyzed by Enzyme Linked Immune Assay.
RESULTS
The concentration of salivary interleukin 6 in oral squamous cell carcinoma patients was higher than control group and it was statistically significant (p < 0.05). The concentration of salivary tumor necrosis factor alpha, interleukin 1 alpha and 8 in case group was higher than control group but it was not statistically significant (p > 0.05).
CONCLUSIONS
These results shows that more studies are needed to accept the utility of these cytokines in predicting or diagnosis of oral squamous cell carcinoma or evaluation of treatment.
目的
本研究旨在比较口腔鳞状细胞癌患者唾液中肿瘤坏死因子α、白细胞介素1α、6和8的浓度与对照组的差异。
研究设计
本研究纳入18名受试者，其中9例口腔鳞状细胞癌患者和9名年龄、性别匹配且牙龈状况也相匹配的健康个体。唾液采样前1个月内患有活动性牙脓肿、胶原血管疾病和传染病被视为排除标准。收集未刺激的全唾液，样本处理后采用酶联免疫吸附测定法进行分析。
结果
口腔鳞状细胞癌患者唾液中白细胞介素6的浓度高于对照组，且具有统计学意义（p < 0.05）。病例组唾液中肿瘤坏死因子α、白细胞介素1α和8的浓度高于对照组，但无统计学意义（p > 0.05）。
结论
这些结果表明，需要更多研究来证实这些细胞因子在预测或诊断口腔鳞状细胞癌或评估治疗方面的效用。
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