Srivastava Shilpy, Singh Mahender Kumar, Raghava Gajendra P S, Varshney Grish C
Institute of Microbial Technology, Chandigarh, India.
Methods Mol Biol. 2007;409:125-39. doi: 10.1007/978-1-60327-118-9_8.
Haptens are small molecules that are usually nonimmunogenic unless coupled to some carrier proteins. The generation of anti-hapten antibodies is important for the development of immunodiagnostics and therapeutics. Recently, our group has developed a database called HaptenDB, which provides comprehensive information about 1,087 haptens. In this chapter, we describe following web tools integrated in HaptenDB: (i) keyword search facility allows search on major fields, (ii) browsing service, to display all haptens, carrier proteins and antibodies, and (iii) structure similarity search, which allows the users to search their structure against hapten structures.
半抗原是小分子,通常无免疫原性,除非与某些载体蛋白偶联。抗半抗原抗体的产生对于免疫诊断和治疗的发展很重要。最近,我们小组开发了一个名为HaptenDB的数据库,它提供了有关1087种半抗原的全面信息。在本章中,我们描述了HaptenDB中集成的以下网络工具:(i)关键词搜索功能允许在主要字段上进行搜索,(ii)浏览服务,以显示所有半抗原、载体蛋白和抗体,以及(iii)结构相似性搜索,它允许用户将其结构与半抗原结构进行比对搜索。