Giacomini Paul S, Arnold Douglas L
McConnell Brain Imaging Centre, Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Quebec, Canada.
Curr Opin Neurol. 2008 Jun;21(3):272-7. doi: 10.1097/WCO.0b013e328300525b.
To summarize recent developments using non-conventional MRI techniques to measure neuroprotection, repair and plasticity in multiple sclerosis.
Recent advances in our understanding of the pathogenesis of multiple sclerosis, particularly as it relates to the development of chronic disability, have led away from a 'lesion-centric' view of multiple sclerosis towards investigating neurodegeneration and pathology in normal appearing brain tissue. Advanced image processing techniques that measure atrophy globally and regionally also have provided insight into the putative mechanisms that contribute to neurodegeneration. In addition, novel quantitative imaging techniques that are more specific than conventional MRI for myelin and axonal pathology have been instrumental in revealing the dynamic nature of injury and repair of myelin and axons in lesions. Novel imaging techniques that are sensitive to the pathology of myelin and axons that happens in multiple sclerosis also provide a method by which we can measure neuroprotection and test the efficacy of putative therapeutic agents in multiple sclerosis.
Non-conventional MRI techniques have contributed to a greater understanding of the complex pathogenesis of neurodegenerative phenomena that occur in multiple sclerosis. The pathological specificity of these novel imaging methods enables the evaluation of the neuroprotective effects of novel therapeutic strategies.
总结利用非传统MRI技术测量多发性硬化症神经保护、修复和可塑性的最新进展。
我们对多发性硬化症发病机制的理解，尤其是与慢性残疾发展相关的机制，有了新进展，这使我们从以“病灶为中心”的多发性硬化症观点转向研究正常脑组织中的神经退行性变和病理。能在全局和区域层面测量萎缩的先进图像处理技术，也为导致神经退行性变的假定机制提供了见解。此外，对于髓鞘和轴索病理比传统MRI更具特异性的新型定量成像技术，有助于揭示病灶中髓鞘和轴索损伤及修复的动态性质。对多发性硬化症中发生的髓鞘和轴索病理敏感的新型成像技术，也提供了一种方法，可用于测量神经保护作用并测试多发性硬化症中假定治疗药物的疗效。
非传统MRI技术有助于更深入地理解多发性硬化症中发生的神经退行性现象的复杂发病机制。这些新型成像方法的病理特异性能够评估新型治疗策略的神经保护作用。
