铜绿假单胞菌中一种假定的乙酰转移酶（PA1377）的结构
Structure of a putative acetyltransferase (PA1377) from Pseudomonas aeruginosa.
作者信息
Davies Anna M, Tata Renée, Chauviac François Xavier, Sutton Brian J, Brown Paul R
机构信息
Randall Division of Cell and Molecular Biophysics, King's College London, New Hunt's House, Guy's Campus, London Bridge, London SE1 1UL, England.
出版信息
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 May 1;64(Pt 5):338-42. doi: 10.1107/S1744309108007665. Epub 2008 Apr 24.
Gene PA1377 from Pseudomonas aeruginosa encodes a 177-amino-acid conserved hypothetical protein of unknown function. The structure of this protein (termed pitax) has been solved in space group I222 to 2.25 A resolution. Pitax belongs to the GCN5-related N-acetyltransferase family and contains all four sequence motifs conserved among family members. The beta-strand structure in one of these motifs (motif A) is disrupted, which is believed to affect binding of the substrate that accepts the acetyl group from acetyl-CoA.
来自铜绿假单胞菌的PA1377基因编码一种功能未知的由177个氨基酸组成的保守假设蛋白。该蛋白（称为pitax）的结构已在空间群I222中解析，分辨率达到2.25埃。Pitax属于与GCN5相关的N - 乙酰转移酶家族，并且包含家族成员中保守的所有四个序列基序。这些基序之一（基序A）中的β链结构被破坏，据信这会影响从乙酰辅酶A接受乙酰基的底物的结合。
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