青春期前社交恐惧症患儿的下丘脑-垂体-肾上腺反应性
Hypothalamic-pituitary-adrenal reactivity in prepubertal children with social phobia.
作者信息
van West Dirk, Claes Stephan, Sulon José, Deboutte Dirk
机构信息
University Center of Child and Adolescent Psychiatry Antwerp (UCKJA), ZNA Middelheim, University of Antwerp, Lindendreef 1, 2020 Antwerp, Belgium.
出版信息
J Affect Disord. 2008 Dec;111(2-3):281-90. doi: 10.1016/j.jad.2008.03.006. Epub 2008 May 2.
BACKGROUND
The aim of this study was to investigate whether a different pattern of HPA axis activity is found between children with social phobia (SP) and healthy control children.
METHODS
A total of 50 prepubertal subjects (25 children with SP and 25 healthy control subjects) were studied. The effects of stress were studied by comparing cortisol responses to a psychosocial stressor, consisting of a public speaking task.
RESULTS
Children with SP showed an elevated cortisol response to the psychosocial stressor as compared with healthy controls. Trait but not state anxiety levels are associated with higher HPA axis activity.
LIMITATIONS
Limited sample size.
CONCLUSIONS
The results indicate that a higher cortisol responsivity to stress may be a neurobiological marker for prepubertal children with SP. Directions for future research and clinical implications are discussed.
背景
本研究旨在调查社交恐惧症（SP）患儿与健康对照儿童之间是否存在不同的下丘脑-垂体-肾上腺（HPA）轴活动模式。
方法
共研究了50名青春期前受试者（25名SP患儿和25名健康对照受试者）。通过比较皮质醇对由公开演讲任务组成的心理社会应激源的反应来研究应激的影响。
结果
与健康对照相比，SP患儿对心理社会应激源的皮质醇反应升高。特质焦虑而非状态焦虑水平与较高的HPA轴活动相关。
局限性
样本量有限。
结论
结果表明，对压力的较高皮质醇反应性可能是青春期前SP患儿的一种神经生物学标志物。讨论了未来研究方向和临床意义。
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