单侧唇腭裂患儿：其父母中6型鼻中隔畸形的发生率。
Unilateral cleft lip/palate children: the incidence of type 6 septal deformities in their parents.
作者信息
Mladina Ranko, Skitarelić Neven, Vuković Katarina, Subarić Marin, Carić Tomislav, Orihovac Zeljko
机构信息
Department of Otolaryngology-Head and Neck Surgery, University Hospital Salata, Zagreb, Croatia.
出版信息
J Craniomaxillofac Surg. 2008 Sep;36(6):335-40. doi: 10.1016/j.jcms.2008.03.003. Epub 2008 May 2.
BACKGROUND
The overall incidence of pathological septal deformity has been found to be significantly higher in unilateral cleft lip/palate (UCLP) children than in control children. Of the seven types of septal deformity according to Mladina's classification, type 6 has been found to be the most frequent in UCLP children, occurring in only 3.7% of the control children.
OBJECTIVE
To investigate the incidence of type 6 septal deformity in the parents of UCLP children.
PATIENTS AND METHODS
UCLP children (N=62) and their parents (N=91) were examined for type 6 septal deformities.
RESULTS
Type 6 was found in at least one parent of a UCLP child in 58% of cases. However, it was not found in the parents whose UCLP children did not show a type 6 septal deformity.
CONCLUSION
Type 6 septal deformity is almost a rule in children suffering from UCLP. Type 6 was not seen in the parents whose UCLP children did not show a type 6 septal deformity. There is a morphogenetic predisposition for the development of CLP in children whose parents carry a type 6 septal deformity.
背景
已发现单侧唇腭裂（UCLP）患儿病理性鼻中隔畸形的总体发生率显著高于对照儿童。根据姆拉迪纳分类法的七种鼻中隔畸形类型中，6型在UCLP患儿中最为常见，而在对照儿童中仅占3.7%。
目的
调查UCLP患儿父母中6型鼻中隔畸形的发生率。
患者与方法
对62例UCLP患儿及其91例父母进行6型鼻中隔畸形检查。
结果
58%的病例中，UCLP患儿的至少一位父母存在6型鼻中隔畸形。然而，在其UCLP患儿未表现出6型鼻中隔畸形的父母中未发现该畸形。
结论
6型鼻中隔畸形在UCLP患儿中几乎是普遍存在的。在其UCLP患儿未表现出6型鼻中隔畸形的父母中未见到6型畸形。父母患有6型鼻中隔畸形的儿童存在唇腭裂发生的形态发生易感性。
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