Tarlinton David, Radbruch Andreas, Hiepe Falk, Dörner Thomas
The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Curr Opin Immunol. 2008 Apr;20(2):162-9. doi: 10.1016/j.coi.2008.03.016. Epub 2008 May 2.
Humoral immunity depends on the regulated production and maintenance of antibody secreting cells during the course of an immune response. Recent insights into the transcriptional regulation of the initiation of plasma cell differentiation have clarified aspects of this process, particularly with respect to the choice between the memory B cell and plasma cell differentiation pathways. It is now possible to specify the conditions favouring these outcomes and to predict where they might occur within the germinal center. Once formed, plasma cell survival is critically dependent on accessing niches that are formed by stomal elements in both normal and inflamed tissues. The apparent homeostasis of plasma cell numbers means that new specificities can persist only at the expense of existing ones, raising questions on how immunological memory is maintained in the face of new immune responses. The answer appears to be through the reduction of the process to a single cell level, thereby introducing an element of stochasticity.
体液免疫依赖于免疫应答过程中抗体分泌细胞的调控产生和维持。最近对浆细胞分化起始的转录调控的深入了解，阐明了这一过程的一些方面，特别是在记忆B细胞和浆细胞分化途径之间的选择方面。现在可以确定有利于这些结果的条件，并预测它们可能在生发中心的何处发生。一旦形成，浆细胞的存活严重依赖于进入由正常和炎症组织中的基质成分形成的微环境。浆细胞数量的明显稳态意味着新的特异性只能以牺牲现有的特异性为代价而持续存在，这就引发了关于在面对新的免疫应答时如何维持免疫记忆的问题。答案似乎是通过将这个过程简化到单细胞水平，从而引入了一个随机性因素。
