Bordier-Lamy F, Palot J-P, Vitry F, Bernard P, Grange F
Service de dermatologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51092 Reims cedex, France.
Ann Dermatol Venereol. 2008 May;135(5):373-9. doi: 10.1016/j.annder.2008.02.016. Epub 2008 Apr 10.
Hidradenitis suppurativa is a chronic disease, severe forms of which may be highly invalidating. Although wide surgery is usually considered the most effective curative therapy, few medical teams in France have extensive experience of this approach. Our aim was to evaluate the clinical history and the results of surgery in all patients operated with curative intent in an experienced centre.
Medical records were reviewed for all patients operated between January 1985 and January 2007. In addition, the patients were contacted by telephone and/or letter and asked about their clinical history, the repercussions of their disease on their daily lives, postsurgical relapse and their overall satisfaction regarding surgery. Separate analyses were carried out for patients and for individual operated sites.
Of 93 patients followed-up for between one and 205 months (mean: 30 months), 209 anatomical sites were operated with curative intent, using either limited excision (i.e. including all visible lesions without margins) or wide excision (i.e. including all lesions with a significant margin). The disease had been present for an average of 7.6 years before surgical treatment, with onset seven years earlier in women. Most patients had previously received multiple and often unsuitable medical treatments. Patients' personal and professional lives were highly affected. Surgery required hospitalization for an average duration of 6.6 days, caused complications in 21% of cases and was often perceived as trying. Relapse in the operated areas occurred in 33% of cases and this was more frequent after limited excision. Nevertheless, 74% of patients were ultimately satisfied with their surgical treatment and most regarded surgery as the only really effective therapy.
Our study confirms the heavy repercussions of hidradenitis suppurativa on patients' day-life as well as the value of surgical management by experienced surgeons.
Wide excision remains the mainstay of therapy in extensive forms of hidradenitis suppurativa. However, this chronic, disseminated and recurrent disease continues to be insufficiently understood and innovative medical approaches, including the development of clinical trials, are required.
化脓性汗腺炎是一种慢性疾病,其严重形式可能会导致患者高度残疾。尽管广泛手术通常被认为是最有效的治疗方法,但法国很少有医疗团队在这种治疗方法上有丰富经验。我们的目的是评估在一个经验丰富的中心,所有接受根治性手术的患者的临床病史和手术结果。
回顾了1985年1月至2007年1月期间所有接受手术患者的病历。此外,通过电话和/或信件联系患者,询问他们的临床病史、疾病对日常生活的影响、术后复发情况以及他们对手术的总体满意度。对患者和各个手术部位分别进行分析。
93例患者的随访时间为1至205个月(平均30个月),209个解剖部位接受了根治性手术,采用有限切除(即包括所有可见病变但无切缘)或广泛切除(即包括所有病变并带有显著切缘)。手术治疗前疾病平均存在7.6年,女性发病时间比男性早7年。大多数患者此前接受过多种且往往不合适的药物治疗。患者的个人生活和职业生活受到严重影响。手术平均住院时间为6.6天,21%的病例出现并发症,患者常认为手术过程很痛苦。33%的病例手术部位出现复发,有限切除后复发更常见。然而,74%的患者最终对手术治疗感到满意,大多数人认为手术是唯一真正有效的治疗方法。
我们的研究证实了化脓性汗腺炎对患者日常生活的严重影响以及经验丰富的外科医生进行手术治疗的价值。
广泛切除仍然是广泛型化脓性汗腺炎治疗的主要方法。然而,这种慢性、弥漫性和复发性疾病仍未得到充分了解,需要创新的医学方法,包括开展临床试验。