Shah J Jina, Maloney Susan A, Liu Yecai, Flagg Elaine W, Johnston Stephanie P, Young Suzanna A, Weston Robert, Merritt Samuel, Wilkins Patricia P, Keane Vincent, Calderon Jaime, Sharp Donald J, Causer Louise, Maguire James H, Cetron Martin S
Centers for Disease Control and Prevention, Atlanta, Georgia 30329-4018, USA.
Am J Trop Med Hyg. 2008 May;78(5):754-9.
We evaluated the effectiveness of an overseas pre-departure regimen of five days of albendazole for presumptive treatment of intestinal parasites by examining stool specimens in treated and untreated Montagnard refugees after arrival in the United States. Among 815 refugees evaluated, fully treated refugees had a significantly lower prevalence of helminths (11 [1.4%] of 777), specifically hookworm and Ascaris lumbricoides, than untreated pregnant women (3 [20%] of 15) (P < 0.001). Multivariate analysis showed that treatment was associated with significantly lower rates of infection with helminths but not protozoa. Post-arrival gastrointestinal symptoms were not associated with findings on stool examination. Our evaluation suggests that although additional studies are needed to determine optimal treatment regimens for intestinal parasites, especially among young children and pregnant women, a five-day course of pre-departure albendazole was effective in reducing helminthic infection in treated refugees.
我们通过检查抵达美国后接受治疗和未接受治疗的孟塔格纳德难民的粪便标本,评估了为期五天的阿苯达唑海外出发前方案对肠道寄生虫假定治疗的有效性。在815名接受评估的难民中,接受充分治疗的难民中蠕虫(777人中有11人[1.4%]),特别是钩虫和蛔虫的感染率显著低于未接受治疗的孕妇(15人中有3人[20%])(P<0.001)。多变量分析表明,治疗与蠕虫感染率显著降低相关,但与原生动物感染率无关。抵达后的胃肠道症状与粪便检查结果无关。我们的评估表明,尽管需要进一步研究以确定肠道寄生虫的最佳治疗方案,尤其是在幼儿和孕妇中,但为期五天的出发前阿苯达唑疗程可有效降低接受治疗难民的蠕虫感染。