Hou Dandan, Tong Xinming, Yu Huaiqing, Zhang Ai-Ying, Feng Zeng-Guo
School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081, People's Republic of China.
Biomed Mater. 2007 Sep;2(3):S147-52. doi: 10.1088/1748-6041/2/3/S12. Epub 2007 Jul 30.
A kind of novel biodegradable supramolecular hydrogel was synthesized via copolymerization of gelatin methacrylamide with photocurable and biodegradable polypseudorotaxanes under UV irradiation. These polypseudorotaxanes were prepared by supramolecular self-assemblies of alpha-cyclodextrins threaded onto amphiphilic LA-PEG-LA copolymers end-capped with methacryloyl groups. The hydrogels are injectable, and their structure was characterized in detail with FTIR, (1)H NMR, XRD, TG and DSC techniques. Their swelling behaviour and morphologies were also examined. The analytical results demonstrated that the channel-type crystalline structure of the polypseudorotaxanes remains in the as-obtained hydrogels. Moreover, the SEM pictures showed that the hydrogels having gelatin methacrylamide are more suitable for cell seeding and proliferation than those without gelatin added.
通过在紫外线照射下使甲基丙烯酰胺明胶与光固化且可生物降解的聚准轮烷共聚，合成了一种新型的可生物降解超分子水凝胶。这些聚准轮烷是通过α-环糊精在两亲性的末端带有甲基丙烯酰基封端的LA-PEG-LA共聚物上进行超分子自组装制备而成。该水凝胶可注射，并用傅里叶变换红外光谱（FTIR）、核磁共振氢谱（¹H NMR）、X射线衍射（XRD）、热重分析（TG）和差示扫描量热法（DSC）技术对其结构进行了详细表征。还研究了它们的溶胀行为和形态。分析结果表明，聚准轮烷的通道型晶体结构保留在所得水凝胶中。此外，扫描电子显微镜（SEM）图片显示，含有甲基丙烯酰胺明胶的水凝胶比未添加明胶的水凝胶更适合细胞接种和增殖。
