胃癌中的HLA-I类分子表达

HLA-class I expression in gastric cancer.

作者信息

Ishigami Sumiya, Natsugoe Shoji, Nakajo Akihiro, Arigami Takaaki, Kitazono Masaki, Okumura Hiroshi, Matsumoto Masataka, Uchikado Yasuto, Setoyama Tetsuro, Sasaki Ken, Aikou Takashi

机构信息

Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, Kagoshima, Japan.

出版信息

J Surg Oncol. 2008 Jun 1;97(7):605-8. doi: 10.1002/jso.21029.

DOI:10.1002/jso.21029

PMID:18459158

Abstract

PURPOSE

We investigated the clinical impact of HLA-class I tumor cells in gastric cancer.

MATERIALS AND METHODS

HLA-class I expression was immunohistochemically evaluated in specimens from 141 gastric cancer patients. The correlation between HLA-class I expression and clinical factors was analyzed.

RESULTS

HLA-class I was identified in 96 (68.1%) gastric carcinomas. The loss of HLA-class I significantly correlated with the depth of invasion (P < 0.01), nodal involvement (P < 0.05) and tumor histology (P < 0.01). According to the positivity of HLA-class I, shallow depth and the absence of nodal metastasis increased. HLA-class I expression was a significant prognostic factor in gastric cancer (P < 0.02); however, HLA-class I was not an independent prognostic factor by multivariate analysis.

CONCLUSIONS

Our data may suggest that loss of HLA-class I in gastric cancer did not directly reflect immunological escape from tumor antigen-specific cytotoxic T lymphocytes, unlike in other cancers.

摘要

目的

我们研究了HLA - I类肿瘤细胞在胃癌中的临床影响。

材料与方法

对141例胃癌患者的标本进行免疫组织化学评估HLA - I类表达。分析HLA - I类表达与临床因素之间的相关性。

结果

96例（68.1%）胃癌中检测到HLA - I类。HLA - I类的缺失与浸润深度（P < 0.01）、淋巴结受累（P < 0.05）和肿瘤组织学（P < 0.01）显著相关。根据HLA - I类的阳性情况，浅浸润深度和无淋巴结转移的情况增加。HLA - I类表达是胃癌的一个重要预后因素（P < 0.02）；然而，多因素分析显示HLA - I类不是一个独立的预后因素。