Sharif Muhammad Ashraf, Mushtaq Sajid, Mamoon Nadira, Khadim Muhammad Tahir
Department of Histopathology, Armed Forces Institute of Pathology, Rawalpindi.
J Coll Physicians Surg Pak. 2008 Mar;18(3):181-2.
Ossifying fibromyxoid tumor is a rare tumor of mesenchymal origin with varied presentation at different sites including head and neck. Clinically these are slow growing lesions and patients have a variable age at presentation. A 14 years old girl presented with a slowly enlarging gingival swelling, which on radiological examination showed increased rarefaction in the mandible with a provisional diagnosis of an inflammatory lesion. Microscopically, the tumor had spindle to oval shaped cells in a fibromyxoid background with a peripheral shell of lamellar bone. Histological diagnosis of ossifying fibromyxoid tumor was made after immunohistochemical stains for vimentin and S-100 protein. Recurrence, metastasis and histologically increased mitotic count are indicative of atypical or malignant ossifying fibromyxoid tumors.
骨化性纤维黏液样肿瘤是一种罕见的间叶源性肿瘤,在包括头颈部在内的不同部位有多种表现。临床上,这些病变生长缓慢,患者就诊时年龄各异。一名14岁女孩出现牙龈肿胀且逐渐增大,影像学检查显示下颌骨骨质稀疏增加,初步诊断为炎性病变。显微镜下,肿瘤在纤维黏液样背景中有梭形至椭圆形细胞,周围有板层骨壳。在进行波形蛋白和S-100蛋白免疫组化染色后,作出了骨化性纤维黏液样肿瘤的组织学诊断。复发、转移以及组织学上有丝分裂计数增加提示为非典型或恶性骨化性纤维黏液样肿瘤。