伴有c-myc与免疫球蛋白基因易位的新发弥漫性大B细胞淋巴瘤的特征分析
Characterization of de novo diffuse large B-cell lymphoma with a translocation of c-myc and immunoglobulin genes.
作者信息
Kikuchi Ako, Nakamura Naoya, Kuze Tetsuo, Sasaki Yoshikazu, Abe Masafumi, Ohno Hitoshi, Akasaka Takashi, Nakamura Shigeo, Ohshima Koichi, Ando Kiyoshi
机构信息
Department of Hematology, Tokai University School of Medicine, Isehara, Japan.
出版信息
Leuk Res. 2008 Aug;32(8):1176-82. doi: 10.1016/j.leukres.2007.10.006.
The characteristics of de novo diffuse large B-cell lymphoma (DLBCL) with translocation of c-myc and immunoglobulin (Ig) genes (c-myc/Ig DLBCL), were investigated in 13 cases of c-myc/Ig DLBCL. Immunohistochemistry revealed five cases were positive for CD10 and BCL6 expression (CD10(+)/BCL6(+)), five cases of CD10(-)/BCL6(+)/MUM1(-), one case of CD10(-)/BCL6(+)/MUM1(+) and two cases of CD10(-)/BCL6(-)/MUM1(+) expression, indicating 10 cases of germinal center B-cell DLBCL and three cases of non-germinal center B-cell DLBCL. Ongoing mutation of the Ig heavy chain gene variable region (IgH-V) was found in two cases with CD10 and BCL6 expression and one case showing CD10(-)/BCL6(+)/MUM1(-) expression. These three cases of ongoing mutation of the IgH-V gene did not express BCL2, unlike those without ongoing mutation. These results suggest a heterogeneous immunophenotype and genotype for c-myc/Ig DLBCL, with CD10(-)/BCL6(+)/MUM1(-) cases the most frequent.
对13例伴有c-myc和免疫球蛋白（Ig）基因易位的初发性弥漫性大B细胞淋巴瘤（DLBCL）（c-myc/Ig DLBCL）的特征进行了研究。免疫组织化学显示，5例CD10和BCL6表达阳性（CD10(+)/BCL6(+)），5例CD10(-)/BCL6(+)/MUM1(-)，1例CD10(-)/BCL6(+)/MUM1(+)，2例CD10(-)/BCL6(-)/MUM1(+)表达，表明10例生发中心B细胞DLBCL和3例非生发中心B细胞DLBCL。在2例CD10和BCL6表达阳性以及1例CD10(-)/BCL6(+)/MUM1(-)表达的病例中发现了Ig重链基因可变区（IgH-V）的持续突变。与未发生持续突变的病例不同，这3例IgH-V基因持续突变的病例不表达BCL2。这些结果表明c-myc/Ig DLBCL具有异质性免疫表型和基因型，其中CD10(-)/BCL6(+)/MUM1(-)病例最为常见。
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