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[肺癌——综述]

[Lung cancer--review].

作者信息

Gudbjartsson Tómas, Smáradottir Agnes, Skúladóttir Halla, Grímsson Hlynur N, Hardardóttir Hrönn, Björnsson Jóhannes, Hannesson Pétur, Haraldsdóttir Sigrídur Olína, Jónsson Steinn

机构信息

Hjarta- og lungnaskurddeild, Landspítala, Reykjavík.

出版信息

Laeknabladid. 2008 Apr;94(4):297-311.

Abstract

Lung cancer is the second most common cancer in Iceland and the most frequent cause of cancer related deaths. Smoking is by far the most important cause but familial factors also contribute. The symptoms of lung cancer are often subtle and the diagnosis, in about 70% of cases, is made when metastases have occurred. Curative surgical treatment is therefore only possible in about a third of the cases whereas other patients receive chemotherapy and/or radiation therapy. In recent years some important advances have been made in the diagnostic and therapeutic approaches to lung cancer. New imaging techniques have improved diagnosis and staging practices and consequently also treatment. Recent evidence suggests that screening with low dose CT may improve survival. New approaches to chemotherapy have been shown to improve survival and well being of patients with advanced disease. Chemotherapeutic agents are now being used in conjunction with surgery to reduce the risk of tumour spread. Furthermore, advances in surgical techniques have made resections possible in cases deemed inoperable in the past. In this review we present important advances in the diagnosis and treatment of lung cancer as reflected by recent literature that should be of interest to a wide variety of specialists.

摘要

肺癌是冰岛第二常见的癌症,也是癌症相关死亡的最常见原因。吸烟是迄今为止最重要的病因,但家族因素也有影响。肺癌症状往往不明显,约70%的病例在出现转移时才得以诊断。因此,只有约三分之一的病例能够进行根治性手术治疗,而其他患者则接受化疗和/或放疗。近年来,肺癌的诊断和治疗方法取得了一些重要进展。新的成像技术改善了诊断和分期实践,从而也改善了治疗。最近的证据表明,低剂量CT筛查可能提高生存率。新的化疗方法已被证明可提高晚期患者的生存率和生活质量。化疗药物现在与手术联合使用以降低肿瘤扩散风险。此外,手术技术的进步使得过去被认为无法手术的病例现在也能够进行切除。在本综述中,我们将介绍近期文献所反映的肺癌诊断和治疗方面的重要进展,这些进展应该会引起广泛的专科医生的兴趣。

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