Many men experience sexual function disorders, the most common of which are PE and ED. However, they may hesitate to seek treatment because of the perceived embarrassment associated with discussing their symptoms with a physician. The introduction of PDE-5 inhibitors for the treatment of ED has resulted in increased awareness of men's sexual health; as a result, men may be more willing to discuss their symptoms of sexual dysfunction because they are aware that treatment options are available. An accurate diagnosis is important for effective treatment of sexual dysfunctions and depends on a detailed description of patient symptoms along with a complete sexual history. When forming a diagnosis, physicians must distinguish PE from ED and other sexual dysfunctions. To diagnose PE, a physician should incorporate measures that include personal distress and interpersonal difficulty between the patient and his partner. Premature ejaculation affects many men, and current pharmacologic treatment options are limited to off-label use of medications indicated for the treatment of depression or the distinct sexual dysfunction, ED. Therefore, the development of new pharmacologic treatments for PE is warranted.