抗菌3-取代6-苯胺基尿嘧啶的合成改进
Improved synthesis of antibacterial 3-substituted 6-anilinouracils.
作者信息
Svenstrup Niels, Kuhl Alexander, Ehlert Kerstin, Häbich Dieter
机构信息
Bayer HealthCare AG, Aprather Weg, D-42096 Wuppertal, Germany.
出版信息
Bioorg Med Chem Lett. 2008 Jun 1;18(11):3215-8. doi: 10.1016/j.bmcl.2008.04.061. Epub 2008 Apr 26.
PMID:18468893
Abstract
3-Substituted 6-anilinouracils, presently the most promising class of inhibitors of the bacterial DNA polymerase in Gram-positive bacteria, have been prepared by a general and straightforward three-step procedure starting from a readily available 1-benzyloxymethyl-protected derivative of 6-chlorouracil.
摘要
3-取代的6-苯胺基尿嘧啶目前是革兰氏阳性菌中最有前景的一类细菌DNA聚合酶抑制剂，它是通过一个通用且直接的三步程序，从一种易于获得的6-氯尿嘧啶的1-苄氧基甲基保护衍生物开始制备的。
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