大吴风草素A，一种来自大吴风草的具有独特碳骨架的新型倍半萜内酯二聚体。
Ainsliadimer A, a new sesquiterpene lactone dimer with an unusual carbon skeleton from Ainsliaea macrocephala.
作者信息
Wu Zhi-Jun, Xu Xi-Ke, Shen Yun-Heng, Su Juan, Tian Jun-Mian, Liang Shuang, Li Hui-Liang, Liu Rui-Hui, Zhang Wei-Dong
机构信息
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, PR China.
出版信息
Org Lett. 2008 Jun 19;10(12):2397-400. doi: 10.1021/ol800656q. Epub 2008 May 17.
A phytochemical investigation of Ainsliaea macrocephala led to the isolation of a new dimeric sesquiterpene lactone, ainsliadimer A (1). The structure of 1 was elucidated by spectroscopic analysis, and confirmed by single crystal X-ray diffraction. Ainsliadimer A represents an unusual carbon skeleton with a cyclopentane system connecting the two monomeric sesquiterpene lactone units. This unique molecule exerted potent inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by LPS.
对大头兔儿风进行植物化学研究，从中分离出一种新的二聚倍半萜内酯——兔儿风二聚体A（1）。通过光谱分析阐明了1的结构，并经单晶X射线衍射确证。兔儿风二聚体A具有不寻常的碳骨架，有一个环戊烷体系连接两个单体倍半萜内酯单元。这种独特的分子对脂多糖刺激的RAW264.7细胞中一氧化氮的产生具有强大的抑制活性。
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