Rennert G, Rennert H S, Epstein L
Department of Family and Community Health, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):721-6. doi: 10.1164/ajrccm/143.4_Pt_1.721.
Lung cancer rates in Israel are lower than in Western countries, not explainable by smoking habits. Because of the different relations of squamous cell carcinoma and adenocarcinoma to smoking it was of interest to study the histologic distribution in Israel. A total of 7,871 histologically confirmed lung cancer cases were studied in the period 1962-1982. Squamous cell carcinoma was the leading tumor type in Jewish men and adenocarcinoma in Jewish women. Rates of both adenocarcinoma and squamous cell carcinoma increased throughout the period in both Jewish men and women, but the increase in adenocarcinoma was more pronounced in the last study period than that in squamous cell carcinoma. In 1977-1982 the rate ratio of squamous cell carcinoma to adenocarcinoma among Jewish men was 1.7. In Arab men it was 2.9, and in Jewish women 0.57. The Kreyberg I/II ratio among Jewish men was about 2.7 with no clear trend throughout the study period, and among Arab men this gradually decreased from 8.1 to 3.5. Jewish women had a constant Kreyberg I/II ratio of about 1 through the whole study period, but the ratio in Arab women was significantly higher than 1, with a mean overall ratio of 3.2. Jews and Arabs in Israel are different from each other in their patterns of lung cancer histology and are different to some extent from other populations in the Western world.
以色列的肺癌发病率低于西方国家，这无法用吸烟习惯来解释。由于鳞状细胞癌和腺癌与吸烟的关系不同，因此研究以色列的组织学分布情况很有意义。在1962年至1982年期间，共对7871例经组织学确诊的肺癌病例进行了研究。鳞状细胞癌是犹太男性中主要的肿瘤类型，腺癌是犹太女性中主要的肿瘤类型。在整个研究期间，犹太男性和女性的腺癌和鳞状细胞癌发病率均有所上升，但在最后一个研究阶段，腺癌发病率的上升比鳞状细胞癌更为明显。1977年至1982年期间，犹太男性中鳞状细胞癌与腺癌的发病率之比为1.7。在阿拉伯男性中为2.9，在犹太女性中为0.57。犹太男性中克雷伯格I/II比例约为2.7，在整个研究期间没有明显趋势，而在阿拉伯男性中，这一比例从8.1逐渐降至3.5。在整个研究期间，犹太女性的克雷伯格I/II比例一直约为1，但阿拉伯女性的这一比例明显高于1，总体平均比例为3.2。以色列的犹太人和阿拉伯人在肺癌组织学模式上彼此不同，并且在一定程度上与西方世界的其他人群也有所不同。
