更换为低出生体重儿配方奶喂养后随即发生的暴发性坏死性小肠结肠炎。
Fulminant necrotising enterocolitis immediately following change to low birth weight formula feeds.
作者信息
Hammond P J, Flett M E, De La Hunt M
机构信息
Department of Paediatric Surgery, Royal Hospital for Sick Children, Yorkhill, Glasgow, United Kingdom.
出版信息
Eur J Pediatr Surg. 2008 Jun;18(3):185-7. doi: 10.1055/s-2008-1038440.
INTRODUCTION
The aim of this study was to investigate how low birth weight formula (LBWF) feeds may be implicated in the pathogenesis of a particularly fulminant form of necrotising enterocolitis (NEC).
MATERIALS AND METHODS
A retrospective case note review was undertaken of cases of fulminant NEC between 1997 and 2003 with particular regard to the feeding history.
RESULTS
Nine preterm infants were stable and already tolerating full enteral feeds for a median of seven days prior to developing fulminant NEC within a median of 24 hours following the introduction of LBWF.
CONCLUSIONS
Although fortification of feeds undoubtedly benefits many premature neonates, there may be a tendency for LBWF feeds to preempt the development of fulminant NEC. This possible temporal association between LBWF and fulminant NEC requires further investigation.
引言
本研究的目的是调查低出生体重配方奶（LBWF）喂养可能如何与一种特别暴发性坏死性小肠结肠炎（NEC）的发病机制相关。
材料与方法
对1997年至2003年间暴发性NEC病例进行回顾性病例记录审查，特别关注喂养史。
结果
9名早产儿在引入LBWF后的中位数为24小时内发生暴发性NEC之前，已稳定并耐受全肠内喂养，中位数为7天。
结论
尽管强化喂养无疑使许多早产新生儿受益，但LBWF喂养可能有引发暴发性NEC的倾向。LBWF与暴发性NEC之间这种可能的时间关联需要进一步研究。
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