Boattini Alessio, Blanco Villegas María José, Pettener Davide
Dipartimento di Biologia Evoluzionistica Sperimentale, Area di Antropologia, Università di Bologna, Via Selmi 3, 40126 Bologna, Italy.
Hum Biol. 2007 Dec;79(6):649-66. doi: 10.1353/hub.2008.0009.
The genetic structure of La Cabrera (province of Léon, Spain), a highly isolated and inbred population (alpha3 = 0.00482), is analyzed by applying multivariate methods (nonmetric multidimensional scaling, Mantel test, Monmonier's algorithm) to different biodemographic data sets. Isonymy, parent-offspring migration (total, males, females), and marital migration matrices were obtained from 5,714 marriages recorded in 37 parishes (clustered in 4 municipalities) between 1880 and 1989. The aim of the study is to investigate the relationships between the genetic and geographic structures of the area. Endemicity values (diagonal of parent-offspring migration matrices), calculated for both sexes at two hierarchical levels (parishes and municipalities), show that female mobility follows the virilocal migration model at the higher (municipalities) level and the uxorilocal model at the parish level. Analysis of isonymy and parent-offspring migration matrices shows high correspondence between the genetic structure and geographic location of the parishes. In fact, the main reproductive barriers, constructed using Monmonier's algorithm, generally coincide with geographic barriers, highlighting increasing isolation patterns from northwest to southeast. Moreover, the analysis of isonymous relationships, which are influenced by earlier population movements, identifies three parishes whose outlier positions are explained by historical-cultural or geographic reasons. The positive and highly significant values (0.32 < or = r < or = 0.51;p < or = 0.001) given by the Mantel tests underline the dependence of the genetic structure on geographic distance. In confirmation of the endemicity results, the lowest correlation value (r = 0.32) is given by the female migration matrix. When the outlier parishes are omitted from the analysis, the correlation between isonymy and geographic distance increases from 0.35 to 0.46, and the values from the other migration matrices remain unchanged. In conclusion, the combination of different data sets and methods allows a wider and more coherent reconstruction of the historical changes in the genetic structure of the La Cabrera population.
通过对不同生物人口学数据集应用多变量方法（非度量多维尺度分析、曼特尔检验、蒙莫尼尔算法），对西班牙莱昂省高度隔离且近亲繁殖的拉卡布雷拉人群（α3 = 0.00482）的遗传结构进行了分析。从1880年至1989年在37个教区（分为4个市镇）记录的5714桩婚姻中获取了同姓名率、亲子迁移（总计、男性、女性）和婚姻迁移矩阵。本研究的目的是调查该地区遗传结构与地理结构之间的关系。在教区和市镇两个层次水平上为两性计算的地方病值（亲子迁移矩阵的对角线）表明，女性流动性在较高（市镇）水平上遵循从夫居迁移模式，而在教区水平上遵循从妻居模式。对同姓名率和亲子迁移矩阵的分析表明，教区的遗传结构与地理位置之间具有高度对应性。事实上，使用蒙莫尼尔算法构建的主要生殖障碍通常与地理障碍相吻合，突出了从西北到东南日益增强的隔离模式。此外，受早期人口迁移影响的同姓名关系分析确定了三个教区，其异常位置可由历史文化或地理原因来解释。曼特尔检验给出的正且高度显著的值（0.32≤r≤0.51；p≤0.001）强调了遗传结构对地理距离的依赖性。为证实地方病结果，女性迁移矩阵给出的相关值最低（r = 0.32）。当从分析中剔除异常教区时，同姓名率与地理距离之间的相关性从0.35增加到0.46，而其他迁移矩阵的值保持不变。总之，不同数据集和方法的结合使得能够更广泛、更连贯地重建拉卡布雷拉人群遗传结构的历史变化。
