视网膜双极细胞中的前馈侧向抑制：水平细胞 - 去极化双极细胞突触的输入 - 输出关系。
Feedforward lateral inhibition in retinal bipolar cells: input-output relation of the horizontal cell-depolarizing bipolar cell synapse.
作者信息
Yang X L, Wu S M
机构信息
Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.
出版信息
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3310-3. doi: 10.1073/pnas.88.8.3310.
Abstract
Lateral inhibition is the ubiquitous strategy used by visual neurons for spatial resolution throughout the animal kingdom. It has been a puzzle whether lateral inputs in retinal bipolar cells are mediated by the horizontal cell (HC)-cone feedback synapse, by the HC-bipolar cell feedforward synapse, or by both. By blocking the central inputs of the depolarizing bipolar cells (DBCs) with L-2-amino-4-phosphonobutyrate, we were able to eliminate the contribution of the feedback synapse and to demonstrate the postsynaptic light response in DBCs mediated by the HC-DBC feedforward synapse. The HC-DBC feedforward synapse contributes roughly one-third of the surround response whereas the HC-cone-DBC feedback synapse probably contributes the rest.
摘要
侧向抑制是视觉神经元在整个动物界用于空间分辨率的普遍策略。视网膜双极细胞中的侧向输入是由水平细胞（HC）-视锥细胞反馈突触、HC-双极细胞前馈突触介导，还是由两者共同介导，一直是个谜。通过用L-2-氨基-4-膦酰丁酸阻断去极化双极细胞（DBC）的中央输入，我们能够消除反馈突触的贡献，并证明由HC-DBC前馈突触介导的DBC中的突触后光反应。HC-DBC前馈突触对周围反应的贡献约为三分之一，而HC-视锥细胞-DBC反馈突触可能贡献其余部分。
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