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Feedforward lateral inhibition in retinal bipolar cells: input-output relation of the horizontal cell-depolarizing bipolar cell synapse.视网膜双极细胞中的前馈侧向抑制：水平细胞 - 去极化双极细胞突触的输入 - 输出关系。
Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3310-3. doi: 10.1073/pnas.88.8.3310.
2
Input-output relations of the feedback synapse between horizontal cells and cones in the tiger salamander retina.虎蝾螈视网膜中水平细胞与视锥细胞之间反馈突触的输入-输出关系。
J Neurophysiol. 1991 May;65(5):1197-206. doi: 10.1152/jn.1991.65.5.1197.
3
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Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina.视杆和视锥双极细胞输入对小鼠视网膜AII无长突细胞光反应的相对贡献。
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Rod Bipolar Cells Require Horizontal Cells for Invagination Into the Terminals of Rod Photoreceptors.视杆双极细胞需要水平细胞才能内陷至视杆光感受器的终末。
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本文引用的文献

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Receptive fields, binocular interaction and functional architecture in the cat's visual cortex.猫视觉皮层中的感受野、双眼相互作用及功能结构
J Physiol. 1962 Jan;160(1):106-54. doi: 10.1113/jphysiol.1962.sp006837.
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Discharge patterns and functional organization of mammalian retina.哺乳动物视网膜的放电模式与功能组织。
J Neurophysiol. 1953 Jan;16(1):37-68. doi: 10.1152/jn.1953.16.1.37.
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Physiological and morphological identification of amacrine cells in the retina of the larval tiger salamander.
Vision Res. 1981;21(8):1307-17. doi: 10.1016/0042-6989(81)90236-4.
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Lateral interactions in absence of feedback to cones.
J Neurophysiol. 1983 Apr;49(4):1007-16. doi: 10.1152/jn.1983.49.4.1007.
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Formation of receptive fields and synaptic inputs to horizontal cells.水平细胞感受野的形成及突触输入
Prog Clin Biol Res. 1982;113:181-92.
6
The release of gamma-aminobutyric acid from horizontal cells of the goldfish (Carassius auratus) retina.金鱼（Carassius auratus）视网膜水平细胞中γ-氨基丁酸的释放。
J Physiol. 1984 Oct;355:191-214. doi: 10.1113/jphysiol.1984.sp015414.
7
2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research.2-氨基-4-膦酰丁酸：视网膜研究的一种新型药理学工具。
Science. 1981 Jan 9;211(4478):182-5. doi: 10.1126/science.6255566.
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An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons.一种兴奋性氨基酸拮抗剂可阻断视锥细胞向信号保守型二阶视网膜神经元的输入。
Science. 1983 Mar 11;219(4589):1230-2. doi: 10.1126/science.6131536.
9
Organization of retina of the mudpuppy, Necturus maculosus. I. Synaptic structure.泥螈（Necturus maculosus）视网膜的组织结构。I. 突触结构。
J Neurophysiol. 1969 May;32(3):315-38. doi: 10.1152/jn.1969.32.3.315.
10
Receptive fields of cones in the retina of the turtle.海龟视网膜中视锥细胞的感受野。
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视网膜双极细胞中的前馈侧向抑制：水平细胞 - 去极化双极细胞突触的输入 - 输出关系。

Feedforward lateral inhibition in retinal bipolar cells: input-output relation of the horizontal cell-depolarizing bipolar cell synapse.

作者信息

Yang X L, Wu S M

机构信息

Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030.

出版信息

Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3310-3. doi: 10.1073/pnas.88.8.3310.

DOI:10.1073/pnas.88.8.3310
PMID:1849650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC51436/
Abstract

Lateral inhibition is the ubiquitous strategy used by visual neurons for spatial resolution throughout the animal kingdom. It has been a puzzle whether lateral inputs in retinal bipolar cells are mediated by the horizontal cell (HC)-cone feedback synapse, by the HC-bipolar cell feedforward synapse, or by both. By blocking the central inputs of the depolarizing bipolar cells (DBCs) with L-2-amino-4-phosphonobutyrate, we were able to eliminate the contribution of the feedback synapse and to demonstrate the postsynaptic light response in DBCs mediated by the HC-DBC feedforward synapse. The HC-DBC feedforward synapse contributes roughly one-third of the surround response whereas the HC-cone-DBC feedback synapse probably contributes the rest.

摘要

侧向抑制是视觉神经元在整个动物界用于空间分辨率的普遍策略。视网膜双极细胞中的侧向输入是由水平细胞（HC）-视锥细胞反馈突触、HC-双极细胞前馈突触介导，还是由两者共同介导，一直是个谜。通过用L-2-氨基-4-膦酰丁酸阻断去极化双极细胞（DBC）的中央输入，我们能够消除反馈突触的贡献，并证明由HC-DBC前馈突触介导的DBC中的突触后光反应。HC-DBC前馈突触对周围反应的贡献约为三分之一，而HC-视锥细胞-DBC反馈突触可能贡献其余部分。