Van Troys Marleen, Huyck Lynn, Leyman Shirley, Dhaese Stien, Vandekerkhove Joël, Ampe Christophe
Department of Medical Protein Research, VIB, B-9000 Ghent, Belgium.
Eur J Cell Biol. 2008 Sep;87(8-9):649-67. doi: 10.1016/j.ejcb.2008.04.001. Epub 2008 May 21.
The actin-binding proteins of the actin-depolymerisation factor (ADF)/cofilin family were first described more than three decades ago, but research on these proteins still occupies a front role in the actin and cell migration field. Moreover, cofilin activity is implicated in the malignant, invasive properties of cancer cells. The effects of ADF/cofilins on actin dynamics are diverse and their regulation is complex. In stimulated cells, multiple signalling pathways can be initiated resulting in different activation/deactivation switches that control ADF/cofilin activity. The output of this entire regulatory system, in combination with spatial and temporal segregation of the activation mechanisms, underlies the contribution of ADF/cofilins to various cell migration/invasion phenotypes. In this framework, we describe current views on how ADF/cofilins function in migrating and invading cells.
肌动蛋白解聚因子（ADF）/丝切蛋白家族的肌动蛋白结合蛋白在三十多年前首次被描述，但对这些蛋白的研究在肌动蛋白和细胞迁移领域仍占据前沿地位。此外，丝切蛋白活性与癌细胞的恶性侵袭特性有关。ADF/丝切蛋白对肌动蛋白动力学的影响是多样的，其调节也很复杂。在受刺激的细胞中，可以启动多种信号通路，从而产生控制ADF/丝切蛋白活性的不同激活/失活开关。整个调节系统的输出，结合激活机制的时空分离，构成了ADF/丝切蛋白对各种细胞迁移/侵袭表型的贡献基础。在此框架下，我们描述了目前关于ADF/丝切蛋白在迁移和侵袭细胞中如何发挥作用的观点。
