2-吡啶酮作为炭疽芽孢杆菌烯脂酰-ACP还原酶新型抑制剂的设计与合成
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase.
作者信息
Tipparaju Suresh K, Joyasawal Sipak, Forrester Sara, Mulhearn Debbie C, Pegan Scott, Johnson Michael E, Mesecar Andrew D, Kozikowski Alan P
机构信息
Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, USA.
出版信息
Bioorg Med Chem Lett. 2008 Jun 15;18(12):3565-9. doi: 10.1016/j.bmcl.2008.05.004. Epub 2008 May 4.
Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.
来自炭疽芽孢杆菌的烯酰基-ACP还原酶（ENR）是FabI基因的产物，负责催化细菌脂肪酸生物合成的最后一步。合成了许多新型2-吡啶酮衍生物，它们被证明是BaENR的有效抑制剂。
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