Rizos E N, Rontos I, Laskos E, Arsenis G, Michalopoulou P G, Vasilopoulos D, Gournellis R, Lykouras L
University of Athens, Medical School, 2nd Department of Psychiatry, Attikon General Hospital, Greece.
Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1308-11. doi: 10.1016/j.pnpbp.2008.04.007. Epub 2008 Apr 16.
The role of brain-derived neurotrophic factor (BDNF) is to promote and modulate the neuronal responses across neurotransmitter systems in the brain. Therefore, abnormal BDNF signaling may be associated with the pathophysiology of schizophrenia. Decreased BDNF levels in the brain and the serum of patients with psychotic disorders have been reported. In the present study, we assessed serum BDNF levels in a group of 14 drug-naive first-episode patients with schizophrenia (FEP), compared to 15 healthy controls. The serum BDNF levels in the sample of FEP patients was significantly reduced compared to normal controls (23.92+/-5.99 ng/ml vs. 30.0+/-8.43 ng/ml, F=5.01, df=1, p=.034). Negative correlations were shown between serum BDNF levels of the patients and the PANSS Positive and Negative subscale scores. Our findings indicate that BDNF levels at the onset of schizophrenia may reflect associated pathophysiological processes as well as the severity of positive and negative psychotic symptoms.
脑源性神经营养因子（BDNF）的作用是促进和调节大脑中跨神经递质系统的神经元反应。因此，BDNF信号异常可能与精神分裂症的病理生理学有关。有报道称，精神病患者大脑和血清中的BDNF水平降低。在本研究中，我们评估了一组14例未服用过药物的首发精神分裂症患者（FEP）的血清BDNF水平，并与15名健康对照者进行了比较。与正常对照组相比，FEP患者样本中的血清BDNF水平显著降低（23.92±5.99 ng/ml对30.0±8.43 ng/ml，F=5.01，自由度=1，p=0.034）。患者的血清BDNF水平与阳性和阴性症状评定量表（PANSS）的阳性和阴性分量表得分呈负相关。我们的研究结果表明，精神分裂症发病时的BDNF水平可能反映了相关的病理生理过程以及阳性和阴性精神病症状的严重程度。
