Upadhyay Rohit, Jain Meenu, Kumar Shaleen, Ghoshal Uday Chand, Mittal Balraj
Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareilly Road, Lucknow-226014, India.
Clin Immunol. 2008 Aug;128(2):199-204. doi: 10.1016/j.clim.2008.03.519. Epub 2008 May 27.
Chronic inflammation plays a role in transformation from normal cell to malignant state. Interleukin-6 (IL-6) regulates inflammation and various physiological processes. IL-6 promoter polymorphism (-174G>C) is associated with transcription differences in vitro and in vivo. High expression of IL-6 may result in oxidative DNA damage and enhance risk of carcinogenesis. Therefore, we aimed to evaluate association of IL-6 -174G>C polymorphism with predisposition to esophageal cancer (EC) in 369 subjects (168 patients with EC and 201 controls). We observed significant association of IL-6 -174C non-carrier genotype with risk of EC, (OR=2.29; P=0.001), with squamous cell carcinoma (SCC) histology (OR=2.26; P=0.001) and tumor at upper and lower anatomical locations (OR=5.97; P=0.009 and OR=2.34; P=0.034). Patients having IL-6 -174C non-carrier genotype were at elevated risk of metastasis (OR=2.49; P=0.005). In conclusion, IL-6 -174G>C gene polymorphism may confer high risk for EC and its clinical characteristics.
慢性炎症在正常细胞向恶性状态的转变中起作用。白细胞介素-6（IL-6）调节炎症和各种生理过程。IL-6启动子多态性（-174G>C）与体内外转录差异相关。IL-6的高表达可能导致氧化性DNA损伤并增加致癌风险。因此，我们旨在评估369名受试者（168例食管癌患者和201例对照）中IL-6 -174G>C多态性与食管癌（EC）易感性的关联。我们观察到IL-6 -174C非携带者基因型与EC风险（OR=2.29；P=0.001）、鳞状细胞癌（SCC）组织学（OR=2.26；P=0.001）以及上、下解剖部位肿瘤（OR=5.97；P=0.009和OR=2.34；P=0.034）之间存在显著关联。具有IL-6 -174C非携带者基因型的患者转移风险升高（OR=2.49；P=0.005）。总之，IL-6 -174G>C基因多态性可能使患EC及其临床特征的风险升高。
