O'Hara Jennifer R, Buret Andre G
Department of Biological Sciences, Inflammation Research Network, University of Calgary, Calgary, AB, Canada.
Front Biosci. 2008 May 1;13:7008-21. doi: 10.2741/3206.
Tight junctions are dynamic structures that may undergo structural and functional changes in response to both physiological and pathological circumstances. Several microbial pathogens impair intestinal barrier function by exploiting tight junctions. These pathogens have developed a broad and complex range of strategies to subvert host tight junction barrier function. The purpose of this review is to give an overview of the mechanisms whereby select enteric viruses, bacterial pathogens and parasites modulate intestinal tight junctional structure and function and how these effects may contribute to the development of chronic intestinal disorders.
紧密连接是动态结构，可能会根据生理和病理情况发生结构和功能变化。几种微生物病原体通过利用紧密连接来损害肠道屏障功能。这些病原体已开发出广泛而复杂的策略来破坏宿主紧密连接屏障功能。本综述的目的是概述特定肠道病毒、细菌病原体和寄生虫调节肠道紧密连接结构和功能的机制，以及这些作用如何可能导致慢性肠道疾病的发生。
