de Sèze M, Ruffion A, Haab F, Chartier-Kastler E, Denys P, Game X, Karsenty G, Kerdraon J, Perrouin-Verbe B, Saussine C, Soler J-M, Amarenco G
Service de médecine physique et de réadaptation, CHU Pellegrin, 33076 Bordeaux cedex, France.
Ann Readapt Med Phys. 2008 May;51(4):315-21. doi: 10.1016/j.annrmp.2008.03.003. Epub 2008 May 7.
Injections of botulinum toxin into the detrusor is a major evolution for treatment of neurogenic bladder. They are now considered as a treatment of choice, safe and efficient, in refractory neurogenic overactivity in catheterized patient. To date, there are no consensual practical guidelines for the follow-up of patients having been treated by intradetrusor botulinum toxin, whatever the indication of the treatment, functional, that is, for improving continence and overactive bladder syndrome or organic, that is, for treatment of high-detrusor pressure and their deleterious impact of urinary tract. This lack of guidelines leads to heterogeneity of treatment management and limit the definition of optimal modalities of intradetrusor botulinum toxin treatment in neurogenic patients. The aim of your work, prepared jointly with the International Francophone Neuro-Urological expert study group (GENULF), aimed at putting forward well-informed specific recommendations for the follow-up of patients having been treated by intradetrusor botulinum toxin for functional or organic indication of neurogenic detrusor overactivity.
向逼尿肌注射肉毒杆菌毒素是神经源性膀胱治疗的一项重大进展。目前,它们被视为导管插入患者难治性神经源性膀胱过度活动症的一种安全有效的首选治疗方法。迄今为止,无论治疗的适应症是功能性的(即改善尿失禁和膀胱过度活动综合征)还是器质性的(即治疗高逼尿肌压力及其对尿路的有害影响),对于接受逼尿肌内注射肉毒杆菌毒素治疗的患者的随访,都没有达成共识的实用指南。这种指南的缺乏导致治疗管理的异质性,并限制了神经源性患者逼尿肌内肉毒杆菌毒素治疗最佳方式的定义。你与国际法语国家神经泌尿学专家研究小组(GENULF)共同开展的这项工作的目的,是针对因功能性或器质性神经源性逼尿肌过度活动而接受逼尿肌内注射肉毒杆菌毒素治疗的患者的随访,提出明智的具体建议。