胃肠道间质瘤：最新进展
Gastrointestinal stromal tumours: an update.
作者信息
Somerhausen N de S, Fletcher C D
机构信息
Department of Pathology Brigham and Women's Hospital and Harvard Medical School 75 Francis Street Boston MA 02115 USA.
出版信息
Sarcoma. 1998;2(3-4):133-41. doi: 10.1080/13577149877885.
Purpose. To study the evolution of concepts concerning gastrointestinal stromal tumours (GISTs) over 30 years.Discussion. GISTs have been, for more than 30 years, the subject of considerable controversy regarding their line of differentiation as well as the prediction of their behaviour. Furthermore, once they spread within the peritoneal cavity, they are extremely hard to control. The recent findings of c-Kit mutations and the immunohistochemical detection of the product of this gene, KIT or CD117, in the mainly non-myogenic subset of this family of tumours, has led to a reappraisal of this group of lesions, which, with some exceptions, is now thought to be derived from the interstitial cells of Cajal, and this has facilitated a clearer definition of their pathological spectrum. In this article, we review chronologically the evolution of the concept of GIST with the gradual application of electron microscopy, immunohistochemistry, DNA ploidy analysis. We discuss the impact of these techniques on the pathological assessment and clinical management of GISTs.
目的。研究30年来关于胃肠道间质瘤（GISTs）概念的演变。讨论。30多年来，GISTs在其分化谱系以及行为预测方面一直存在相当大的争议。此外，一旦它们在腹腔内扩散，就极难控制。最近发现c-Kit基因突变以及在该肿瘤家族主要非肌源性亚群中对该基因产物KIT或CD117进行免疫组化检测，促使人们对这组病变进行重新评估，现在认为除了一些例外情况，它们起源于 Cajal 间质细胞，这有助于更清晰地界定其病理谱。在本文中，我们按时间顺序回顾随着电子显微镜、免疫组化、DNA倍体分析的逐步应用，GIST概念的演变。我们讨论这些技术对GISTs病理评估和临床管理的影响。
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