Barraco R A, Phillis J W
Department of Physiology, Wayne State University, School of Medicine, Detroit, MI 48201.
Neuropharmacology. 1991 Apr;30(4):403-7. doi: 10.1016/0028-3908(91)90067-l.
Microinjections of selective agonists for adenosine receptor subtypes were made into the caudal NTS of rats. CGS 21680, a selective A2 receptor agonist, elicited pronounced, dose-related decreases in mean arterial blood pressure (ED50 = .021 nmols/rat). Conversely, CPA, a selective A1 receptor agonist, elicited potent dose-related increases in mean arterial blood pressure (ED50 = 0.185 nmols/rat). Additionally, the depressor responses elicited by the A2 agonist and the pressor responses elicited by the A1 agonist were completely and selectively blocked, respectively, by the selective A2 antagonist, CGS 15943A, and the selective A1 antagonist, DPCPX. These data indicate that selective activation of brainstem adenosine receptors in vivo may elicit distinct and opposing response patterns.
将腺苷受体亚型的选择性激动剂微量注射到大鼠延髓尾端的孤束核中。选择性A2受体激动剂CGS 21680引起平均动脉血压显著的剂量相关性降低（半数有效量=0.021纳摩尔/大鼠）。相反，选择性A1受体激动剂CPA引起平均动脉血压显著的剂量相关性升高（半数有效量=0.185纳摩尔/大鼠）。此外，A2激动剂引起的降压反应和A1激动剂引起的升压反应分别被选择性A2拮抗剂CGS 15943A和选择性A1拮抗剂DPCPX完全且选择性地阻断。这些数据表明，体内脑干腺苷受体的选择性激活可能引发不同且相反的反应模式。
