Vercruysse J, Dorny P
Laboratorium voor Parasitologie en Parasitaire Ziekten, Faculteit Diergeneeskunde, Gent.
Verh K Acad Geneeskd Belg. 1991;53(2):121-58; discussion 159-62.
The prevention of infections with gastrointestinal nematodes has become an indispensable part of modern farm management in Belgium. It is important that for the choice of the correct preventive strategy the epidemiological situation on the farm is considered. Anthelmintics are mainly used in Belgium for the prevention of gastrointestinal nematodes. The mid-summer rise of the herbage infections can be avoided by either the continuous use or the regular administration of anthelmintics at the beginning of the grazing season. During the last 10 years controlled released devices (CRD) have been developed and made it possible to treat animals before they are turned-out. There are two types of CRD: the pulse and slow release devices, with the oxfendazole pulse release bolus (OPRB) and the morantel slow release trilaminate device (MSR) being used respectively in Belgium. In 9 field trials on commercial farms the effects of different preventive methods were studied. The most efficient preventive methods were the OPRB at turn-out or ivermectin at 3, 8 and 13 weeks post turn-out. Although the MSRT at turn-out and levamisole at 3, 6 and 9 weeks post turn-out apparently has less effect on the parasitological (faecal egg-counts) and serological (pepsinogen, gastrin and Ostertagia ELISA-antibody titers) parameters examined, both systems prevented clinical symptoms. However, the constant use of preventive methods could interfere with the development of immunity against gastrointestinal parasites and/or increase the development of resistance against anthelmintics.
在比利时,预防胃肠道线虫感染已成为现代农场管理不可或缺的一部分。重要的是,在选择正确的预防策略时,要考虑农场的流行病学情况。在比利时,驱虫药主要用于预防胃肠道线虫感染。通过在放牧季节开始时持续使用或定期施用驱虫药,可以避免仲夏时节牧草感染率的上升。在过去10年里,控释装置(CRD)得以开发,使得在动物放牧前就能进行治疗。CRD有两种类型:脉冲式和缓释式装置,在比利时分别使用的是奥芬达唑脉冲释放丸剂(OPRB)和莫仑太尔缓释三层片装置(MSR)。在9个商业农场进行的田间试验中,研究了不同预防方法的效果。最有效的预防方法是放牧时使用OPRB或在放牧后第3、8和13周使用伊维菌素。尽管放牧时使用MSRT以及在放牧后第3、6和9周使用左旋咪唑对所检测的寄生虫学参数(粪便虫卵计数)和血清学参数(胃蛋白酶原、胃泌素和奥斯特他线虫酶联免疫吸附测定抗体滴度)的影响明显较小,但这两种方法都能预防临床症状。然而,持续使用预防方法可能会干扰对胃肠道寄生虫免疫力的发展和/或增加对驱虫药耐药性的发展。