Kitaeva L V, Mikhaĭlova I A, Semov D, Proshin S N, Kravtsov V Iu
Tsitologiia. 2008;50(2):160-4.
International Agency for Research on Cancer recognized as sufficient the evidence of Helicobacter pylori (HP) infection carcinogenicity and placed it into the 1 st group of carcinogens. Micronucleus level in gastric epithelial cells of antral stomach region of patients with chronic non-atrophy gastritis (n = 62) was studied. 40 patients of 62 had HP-associated gastritis. The HP-bacterium exists in a spiral and coccoid form. Both morphological forms were examined using immunocytochemistry. Significantly increased micronucleus number was observed in the cells of HP-infected patients compared with non-infected person (P < 0.05). The frequency of stomach epithelium cells with micronuclei was enhanced considerably in the patients infected with the coccoid HP form. Therefore the patients with HP-associated chronic gastritis caused by the coccoid form with high degree of colonization must be considered as a group of enhanced risk of gastric carcinogenesis.
国际癌症研究机构认为幽门螺杆菌（HP）感染致癌的证据充分，并将其列入第一类致癌物。对慢性非萎缩性胃炎患者（n = 62）胃窦部胃上皮细胞中的微核水平进行了研究。62例患者中有40例患有HP相关性胃炎。HP细菌以螺旋形和球形两种形态存在。使用免疫细胞化学方法对这两种形态进行了检测。与未感染HP的患者相比，HP感染患者细胞中的微核数量显著增加（P < 0.05）。感染球形HP形态的患者胃上皮细胞中出现微核的频率大幅提高。因此，由高度定植的球形HP形态引起的HP相关性慢性胃炎患者必须被视为胃癌发生风险增加的群体。
